DDAVP effects as a painkillerBy Max from NY, NY on January 25, 2006 Category: Desmopressin acetate Dear Sir/Madame I am interested in the mechanism of the immediate effect of intranasal DDAVP. It is stated on FDA site that the onset of DDAVP action is in an hour. At the same time, there are a few references in the pubmed that DDAVP provides good pain relief in renal colic within 30 minutes after intranasal administration. Could you help me explaining what would be the mechanism of this short action? Is it the effect on smooth muscles of the urinary tract - sort of spasmolitic effect? what DDAVP does with endogenous ADH release in the short run? Does it shut it down for a little while, and then overrides the action? you answer will be very much appreciated. maxim signaevsky md, phd |
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