|
Bicalutamide
Bicalutamide (Casodex)
Bicalutamide
(
buy-kah-
LOO-tah-myd)
Pregnancy Category: X
Casodex
(Rx)
Classification:
Antineoplastic, antiandrogen
See Also:
See also
Antineoplastic Agents
[.
]
Action/Kinetics:
A nonsteroidal antiandrogen that competitively inhibits the action of androgens by binding to androgen receptors in the cytosol in target tissues. Well absorbed after PO administration; food does not affect the rate or amount absorbed. Metabolized in the liver, and both parent drug and metabolites are eliminated in the urine and feces.
t
1/2: 5.8 days.
Mean steady-state concentration in prostatic cancer: 8.9 mcg/mL.
Uses:
In combination therapy with a leutinizing hormone
-releasing hormone analog for the treatment of advanced prostate cancer.
Contraindications:
Pregnancy.
Special Concerns:
Use with caution in clients with moderate to severe hepatic impairment and during lactation. Safety and efficacy have not been established in children.
Side Effects:
GI: Constipation, N&V;, diarrhea, anorexia, dyspepsia, rectal hemorrhage, dry mouth, melena.
CNS: Dizziness, paresthesia, insomnia, anxiety, depression, decreased libido, hypertonia, confusion, neuropathy, somnolence, nervousness.
GU: Gynecomastia, nocturia, hematuria, UTI, impotence, urinary incontinence, urinary frequency, impaired urination, dysuria, urinary retention, urinary urgency.
CV: Hot flashes (most common), hypertension, angina pectoris, CHF.
Metabolic: Peripheral edema, hyperglycemia, weight loss or gain, dehydration, gout.
Musculoskeletal: Myasthenia, arthritis, myalgia, leg cramps, pathologic fracture.
Respiratory: Dyspnea, increased cough, pharyngitis, bronchitis, pneumonia, rhinitis, lung disorder.
Dermatologic: Rash, sweating, dry skin, pruritus, alopecia.
Hematologic: Anemia, hypochromic and iron deficiency anemia.
Body as a whole: General pain, back pain, asthenia, pelvic pain, abdominal pain, chest pain, flu syndrome, edema, neoplasm, fever, neck pain, chills,
sepsis.
Miscellaneous: Infection, bone pain, headache, breast pain, diabetes mellitus.
Laboratory Test Alterations:
 Alkaline phosphatase, creatinine, AST, ALT, bilirubin, BUN, liver enzyme tests.
 Hemoglobin, white cell count.
Drug Interactions:
Bicalutamide may displace coumarin anticoagulants from their protein-binding sites, resulting in an increased anticoagulant effect.
How Supplied:
Tablet: 50 mg
Dosage
?Tablets
Prostatic carcinoma.
50 mg (1 tablet) once daily (morning or evening) in combination with an LHRH analog with or without food. |
