Aminophylline
Aminophylline (Truphyllin)
Aminophylline
(am-in- OFF-ih-lin)
Pregnancy Category: C Aminophyllin Jaa Aminophylline Phyllocontin Phyllocontin-350 Truphyllin (Rx)

Classification: Bronchodilator

See Also: See also Theophylline Derivatives .

Action/Kinetics: Contains 79% theophylline.

Additional Uses: Neonatal apnea, respiratory stimulant in Cheyne-Stokes respiration. Parenteral form has been used for biliary colic and as a cardiac stimulant, a diuretic, and an adjunct in treating CHF, although such uses have been replaced by more effective drugs.

Special Concerns: Use with caution when aminophylline and sodium chloride are used with corticosteroids or in clients with edema.

Additional Side Effects: The ethylenediamine in the product may cause exfoliative dermatitis or urticaria.

How Supplied: Injection: 25 mg/mL; Oral Solution: 105 mg/5 mL; Suppository: 250 mg, 500 mg; Tablet: 100 mg, 200 mg

Dosage:
•Oral Solution, Tablets Bronchodilator, acute attacks, in clients not currently on theophylline therapy.
Adults and children up to 16 years of age, loading dose: Equivalent of 5-6 mg of anhydrous theophylline/kg.
Bronchodilator, acute attacks, in clients currently receiving theophylline.
Adults and children up to 16 years of age: If possible, a serum theophylline level should be obtained first. Then, base loading dose on the premise that each 0.5 mg theophylline/kg lean body weight will result in a 0.5-1.6-mcg/mL increase in serum theophylline levels. If immediate therapy is needed and a serum level cannot be obtained, a single dose of the equivalent of 2.5 mg/kg of anhydrous theophylline can be given.
Maintenance in acute attack, based on equivalent of anhydrous theophylline.
Young adult smokers: 4 mg/kg q 6 hr; healthy, nonsmoking adults: 3 mg/kg q 8 hr; geriatric clients or clients with cor pulmonale: 2 mg/kg q 8 hr; clients with CHF or liver failure: 2 mg/kg q 8-12 hr. Pediatric, 12-16 years: 3 mg/kg q 6 hr; 9-12 years: 4 mg/kg q 6 hr; 1-9 years: 5 mg/kg q 6 hr; 6-12 months: Use the formula: dose (mg/kg q 8 hr) = (0.05) (age in weeks) + 1.25; up to 6 months: Use the formula: dose (mg/kg q 8 hr) = (0.07) (age in weeks) + 1.7.
Chronic therapy, based on equivalent of anhydrous theophylline.
Adults, initial: 6-8 mg/kg up to a maximum of 400 mg/day in three to four divided doses at 6-8-hr intervals; then, dose can be increased in 25% increments at 2-3 day intervals up to a maximum of 13 mg/kg or 900 mg/day, whichever is less. Pediatric, initial: 16 mg/kg up to a maximum of 400 mg/day in three to four divided doses at 6-8 hr intervals; then, dose may be increased in 25% increments at 2-3 day intervals up to the following maximum doses (without measuring serum theophylline): 16 years and older: 13 mg/kg or 900 mg/day, whichever is less; 12-16 years: 18 mg/kg/day; 9-12 years: 20 mg/kg/day; 1-9 years: 24 mg/kg/day; up to 12 months, Use the following formula: dose (mg/kg/day) = (0.3) (age in weeks) + 8.0.
•Enteric-Coated Tablets Bronchodilator, chronic therapy, based on equivalent of anhydrous theophylline.
Adults, initial: 6-8 mg/kg up to a maximum of 400 mg/day in three to four divided doses at 6-8-hr intervals; then, dose may be increased, if needed and tolerated, by increments of 25% at 2-3 day intervals up to a maximum of 13 mg/kg/day or 900 mg/day, whichever is less, without measuring serum theophylline. Pediatric, over 12 years of age, initial: 4 mg/kg q 8-12 hr; then, dose may be increased by 2-3 mg/kg/day at 3-day intervals up to the following maximum doses (without measuring serum levels): 16 years and older: 13 mg/kg/day or 900 mg/day, whichever is less; 12-16 years: 18 mg/kg/day.
•Enema
For use as a bronchodilator for loading doses and for maintenance in acute attacks, see doses for oral solution and tablets.
•IV Infusion Bronchodilator, acute attacks, for clients not currently on theophylline.
Adults and children up to 16 years, loading dose based on anhydrous theophylline: 5 mg/kg given over a period of 20 min.
Bronchodilator, acute attack, for clients currently on theophylline.
Adults and children up to 16 years, loading dose based on anhydrous theophylline: If possible, a serum theophylline level should be obtained first. Then, base loading dose on the premise that each 0.5 mg theophylline/kg lean body weight will result in a 0.5-1.6 mcg/mL increase in serum theophylline levels. If immediate therapy is needed and a serum level cannot be obtained, a single dose of the equivalent of 2.5 mg/kg of anhydrous theophylline can be given.
Maintenance for acute attacks, based on equivalent of anhydrous theophylline.
Young adult smokers: 0.7 mg/kg/hr; nonsmoking, healthy adults: 0.43 mg/kg/hr; geriatric clients or clients with cor pulmonale: 0.26 mg/kg/hr; clients with CHF or liver failure: 0.2 mg/kg/hr. Pediatric, 12-16 years, nonsmokers: 0.5 mg/kg/hr; 9-12 years, 0.7 mg/kg/hr; 1-9 years, 0.8 mg/kg/hr; up to 1 year, Based on the following formula: dose (mg/kg/hr) = (0.008) (age in weeks) + 0.21.