Trientine hydrochloride
Trientine hydrochloride (Syprine)
Trientine hydrochloride
( TRY-en-teen)
Pregnancy Category: C Syprine (Rx)

Classification: Chelating agent

Action/Kinetics: A chelating agent that binds copper, thus facilitating its excretion from the body.

Uses: Wilson's disease (a metabolic defect resulting in excess copper accumulation) who are intolerant of penicillamine.

Contraindications: Use in cystinuria, rheumatoid arthritis, biliary cirrhosis.

Special Concerns: Use with caution during lactation. Safety and effectiveness in children have not been determined although the drug has been used in children as young as 6 years of age.

Side Effects: Iron deficiency anemia, SLE.

How Supplied: Capsule: 250 mg

Dosage
?Capsules Wilson's disease.
Adults, initial: 750 mg/day-1.25 g/day in divided doses b.i.d., t.i.d., or q.i.d.; then, may increase to a maximum of 2 g/day. Children less than 12 years of age, initial: 500-750 mg/day in divided doses b.i.d., t.i.d., or q.i.d.; then, may increase to a maximum of 1.5 g/day.