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Action/Kinetics:
Decreases sleep latency, increases the duration of sleep, and decreases the number of awakenings.
Time to peak plasma levels: 0.5-2 hr.
t
1/2: 1.5-5.5 hr. Metabolized in liver; inactive metabolites excreted in the urine.
Uses:
Insomnia (short-term management, not to exceed 1 month). May be beneficial in preventing or treating transient insomnia from a sudden change in sleep schedule.
Contraindications:
Use concomitantly with itraconazole, ketoconazole, nefaxodone. Lactation (may cause sedation and feeding problems in infants).
Special Concerns:
Safety and efficacy in children under 18 years of age not established. Geriatric clients may be more sensitive to the effects of triazolam.
Side Effects:
CNS: Rebound insomnia, anterograde amnesia, headache, ataxia, decreased coordination, ``traveler's'' amnesia. Psychologic and physical dependence.
GI: N&V.;
Drug Interactions:
Triazolam effect when used with azole antifungals, clarithromycin, erythromycin, grapefruit juice, protease inhibitors, and selective serotonin reuptake inihibitors R/T
liver metabolism.
How Supplied:
Tablet: 0.125 mg, 0.25 mg
Dosage
?Tablets
Adults, initial: 0.25-0.5 mg before bedtime.
Geriatric or debilitated clients, initial: 0.125 mg;
then, depending on response, 0.125-0.25 mg before bedtime.
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