Trandolapril
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Classification: Antihypertensive See Also: See also Angiotensin Converting Enzyme (ACE) Inhibitors. Action/Kinetics: Rapidly absorbed; food slows rate, but not amount absorbed. Onset: 2-4 hr. Peak plasma levels, trandolapril: 30-60 min; trandolaprilat: 4-10 hr. t 1/2, trandolapril: About 5 hr; t 1/2, trandoprilat: About 10 hr. Peak effect: 4-10 hr. Metabolized in liver to active trandolaprilat. Duration: 24 hr. About 1/3 trandolaprilat is excreted in urine and 2/3 in feces. Uses: Hypertension, alone or in combination with other antihypertensives such as hydrochlorothiazide. To treat heart failure after MI or ventricular dysfunction after MI. Contraindications: In those with history of angioedema with ACE inhibitors. Special Concerns: Safety and efficacy have not been determined in children. Side Effects: See also ACE Inhibitors. Hypersensitivity: Angioedema. CNS: Dizziness, headache, fatigue, insomnia, paresthesias, drowsiness, vertigo, anxiety. GI: Diarrhea, dyspepsia, gastritis, abdominal pain, vomiting, constipation, pancreatitis. CV: Hypotension, bradycardia, chest pain, cardiogenic shock, intermittent claudication, stroke. Respiratory: Cough, dyspnea, URTI, epistaxis, throat inflammation. Hepatic: Hepatic failure including cholestatic jaundice, fulminant hepatic necrosis, death. Dermatologic: Photosensitivity, pruritus, rash. GU: UTI, impotence, decreased libido. Miscellaneous: Neutropenia, syncope, myalgia, asthenia, muscle cramps, hypocalemia, intermittent claudication, edema, extremity pain, gout. Laboratory Test Alterations: Hyperkalemia, hypocalcemia. Serum uric acid, BUN, creatinine.
Drug Interactions:
How Supplied: Tablet: 1 mg, 2 mg, 4 mg.
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