Terbinafine hydrochloride
Questions | Reviews
Is it possible that taking Terbinafine can develop HIVES?
I just started taking Oral Terbinafin-Lamisil 250mg (twice a day for 7 days) and I've developed big Hives in my forearms, my ankles and my upper abdomin. At times, the itch is unbearable. Help! Are the Hives contagious? My doc said I could put a l...
by Melanie in California, 08/07/2006
Classification: Antifungal agent Action/Kinetics: Inhibits squalene epoxidase, a key enzyme in the sterol biosynthesis in fungi. Results in ergosterol deficiency and a corresponding accumulation of squalene leading to fungal cell death. Approximately 75% of cutaneously absorbed drug is excreted in the urine, mostly as metabolites. Well absorbed following PO administration, with first-pass metabolism being about 40%. Peak plasma levels: 1 mcg/mL within 2 hr. Food enhances absorption. Over 99% bound to plasma proteins. Slowly excreted from adipose tissue and skin. Extensively metabolized with about 70% of the dose eliminated in the urine. Renal or hepatic disease decreases clearance from the body. Uses: Topical use: Interdigital tinea pedis (athletes ' foot), tinea cruris (jock itch), or tinea corporis (ringworm) due to Epidermophyton floccosum, Trichophyton mentagrophytes or T. rubrum. Plantar tinea pedis. Tinea versicolor due to Malassezia furfur. Investigational: Cutaneous candidiasis and tinea versicolor. Oral use: Onychomycosis of the toenail or fingernail due to dermatophytes. Contraindications: Ophthalmic or intravaginal use. PO use in preexisting liver disease or renal impairment (C CR less than 50 mL/min). Lactation. Special Concerns: Safety and efficacy have not been determined in children less than 12 years of age.
Side Effects:
Following topical use. Dermatologic: Irritation, burning, itching, dryness.
Laboratory Test Alterations: Liver enzyme abnormalities that are two or more times the upper limit of the normal range. Absolute neutrophil counts.
Drug Interactions:
How Supplied: Cream: 1%; Spray: 1%; Tablet: 250 mg
Dosage
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