Tamsulosin hydrochloride
Tamsulosin hydrochloride (Flomax)
Tamsulosin hydrochloride
(tam- SOO-loh-sin)
Pregnancy Category: B Flomax (Rx)

Classification: Alpha-1 adrenergic blocking agent

Action/Kinetics: Blockade of alpha-1 receptors (probably alpha _1A) in prostate results in relaxation of smooth muscles in bladder neck and prostate; thus, urine flow rate is improved and there is a decrease in symptoms of BPH. Food interferes with the rate of absorption. t 1/2, elimination: 5-7 hr. Significantly bound to plasma proteins. Extensively metabolized in liver; excreted through urine and feces.

Uses: Treatment of signs and symptoms of BPH. Rule out prostatic carcinoma before using tamsulosin.

Contraindications: Use to treat hypertension, with other alpha-adrenergic blocking agents, or in women or children.

Special Concerns: Use with caution with concurrent administration of warfarin.

Side Effects: Body as a whole: Headache, infection, asthenia, back pain, chest pain. CV: Postural hypotension, syncope. GI: Diarrhea, nausea, tooth disorder. CNS: Dizziness, vertigo, somnolence, insomnia, decreased libido. Respiratory: Rhinitis, pharyngitis, increased cough, sinusitis. GU: Abnormal ejaculation. Miscellaneous: Amblyopia.

Overdose Management: Symptoms: Hypotension. Treatment: Keep client in supine position to restore BP and normalize HR. If this is inadequate, consider IV fluids. Vasopressors may also be used; monitor renal function.

Drug Interactions: Cimetidine causes significant in clearance of tamsulosin.

How Supplied: Capsules: 0.4 mg

Dosage
?Capsules Benign prostatic hypertrophy.
Adult males: 0.4 mg daily given about 30 min after same meal each day. If, after 2 to 4 weeks, clients have not responded, dose can be increased to 0.8 mg daily.