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Action/Kinetics:
Short-acting; often combined with other anti-infectives.
Uses:
UTIs caused by
Escherichia coli, Klebsiella
Enterobacter
Staphylococcus aureus, Proteus mirabilis, and Proteus vulgaris. Chancroid, inclusion conjunctivitis, adjunct in treating chloroquine-resistant strains of
Plasmodium falciparum meningitis caused by
Haemophilus influenzae, meningococcal meningitis for sulfonamide-sensitive group A strains, nocardiosis, with penicillin to treat acute otitis media caused by
H. influenzae rheumatic fever prophylaxis, adjunct with pyrimethamine for toxoplasmosis in selected immunocompromised clients (e.g., those with AIDS, neoplastic disease, or congenital immune compromise), trachoma.
Contraindications:
Use in infants less than 2 months of age unless combined with pyrimethamine to treat congenital toxoplasmosis.
Special Concerns:
Safe use during pregnancy has not been established.
How Supplied:
Tablet: 500 mg
Dosage
?Tablets
General use.
Adults, loading dose: 2-4 g;
maintenance: 2-4 g/day in 3 to 6 divided doses;
infants over 2 months, loading dose: 75 mg/kg/day (2 g/m
2);
maintenance: 150 mg/kg/day (4 g/m
2/day) in 4 to 6 divided doses, not to exceed 6 g/day.
Rheumatic fever prophylaxis.
Under 30 kg: 0.5 g/day;
over 30 kg: 1 g/day.
As adjunct with pyrimethamine in congenital toxoplasmosis.
Infants less than 2 months: 25 mg/kg q.i.d. for 3 to 4 weeks.
Children greater than 2 months: 25-50 mg/kg q.i.d. for 3 to 4 weeks.
