Podofilox
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Classification: Keratolytic Action/Kinetics: An antimitotic agent that causes necrosis of visible wart tissue when applied topically. Small amounts are absorbed into the system 1-2 hr after application. t 1/2: 1-4.5 hr. The drug does not accumulate following multiple treatments. Uses: Topical treatment of external genital warts and perianal warts (gel only). Investigational: Systemically for treatment of cancer. Contraindications: Use of solution or gel for mucous membrane warts or solution for perianal warts. Lactation. Special Concerns: Genital warts must be distinguished from squamous cell carcinoma prior to initiation of treatment. Safety and effectiveness have not been demonstrated in children. Avoid contact with the eyes.
Side Effects:
Solution. D
ermatologic: Commonly, burning, pain, inflammation, erosion, and itching. Also, tenderness, chafing, scarring, vesicle formation, dryness and peeling, tingling, bleeding, ulceration, malodor, crusting edema, foreskin irretraction.
Miscellaneous: Pain with intercourse, insomnia, dizziness, hematuria, vomiting.
Overdose Management: Symptoms: N&V;, diarrhea, fever, altered mental status, hematologic toxicity, peripheral neuropathy, lethargy, tachypnea, respiratory failure hematuria, leukocytosis, pancytosis, renal failure, seizures, coma. Treatment: Wash the skin free of any remaining drug. General supportive therapy to treat symptoms. How Supplied: Solution: 0.5%, Gel: 0.5%
Dosage
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