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Action/Kinetics:
Causes bronchodilation by stimulating beta-2-adrenergic receptors. Has minimal effects on beta-1 receptors. Also inhibits histamine release from mast cells, causes vasodilation, and increases ciliary motility.
Onset, inhalation: Approximately 5 min.
Time to peak effect: 30-60 min.
Duration: 5 hr.
Uses:
Alone or with theophylline or steroids for prophylaxis and treatment of bronchospasm in asthma and other conditions with reversible bronchospasms (e.g., exercise-induced bronchospasm), including bronchitis, emphysema, bronchiectasis, obstructive pulmonary disease.
Contraindications:
Cardiac arrhythmias due to tachycardia; tachycardia caused by digitalis toxicity.
Special Concerns:
Safety and efficacy have not been determined in children less than 12 years of age.
Additional Side Effects:
CV: PVCs, hypotension.
CNS: Hyperactivity, hyperkinesia, anxiety, confusion, depression, fatigue, syncope.
GI: Diarrhea, dry mouth, anorexia, loss of appetite, bad taste or taste change, abdominal pain, abdominal cramps, stomatitis, glossitis.
Dermatologic: Rash, edema, pruritus, alopecia.
Miscellaneous: Flushing, numbness in extremities, weight gain.
How Supplied:
Autohaler or Inhaler: 0.2 mg/inh
Dosage
?Inhalation Aerosol
Bronchodilation.
Adults and children over 12 years: 0.2-0.4 mg (1-2 inhalations) q 4-6 hr, not to exceed 12 inhalations (2.4 mg) daily.
