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Penicillin V potassium
(Phenoxymethyl-penicillin potassium)
Penicillin V potassium (Pen-Vee K, Robicillin VK, V-Cillin K)
Phenoxymethylpenicillin potassium (Pen-Vee K, Robicillin VK, V-Cillin K)
Penicillin V Potassium
(pen-ih-
SILL-in )
Pregnancy Category: B
Apo-Pen-VK
Beepen-VK
Nadopen-V
Novo-Pen-VK
Nu-Pen-VK
Penicillin VK
Pen-Vee K
PVF K
Veetids '250'
(Rx)
Classification:
Antibiotic, penicillin
See Also:
See also
Anti-Infectives
[ and
Penicillins
][.
]
Action/Kinetics:
Related closely to penicillin G. Products are not penicillinase resistant but are acid stable and resist inactivation by gastric secretions. Well absorbed from the GI tract and not affected by foods.
Peak plasma levels: Penicillin V,
PO: 2.7 mcg/mL after 30-60 min; penicillin V potassium,
PO: 1-9 mcg/mL after 30-60 min.
t
1/2: 30 min. Periodic blood counts and renal function tests are indicated during long-term usage.
Uses:
Mild to moderate upper respiratory tract streptococcal infections, including scarlet fever and erysipelas. Mild to moderate upper respiratory tract pneumococcal infections, including otitis media. Mild staphylococcal infections of the skin and soft tissue. Mild to moderate fusospirochetosis (Vincent's infection) of the oropharynx. Prophylaxis of recurrence following rheumatic fever or chorea.
Investigational: Prophylactially to reduce
S. pneumoniae septicemia in children with sickle cell anemia, mild to moderate anaerobic infections, Lyme disease.
Contraindications:
PO penicillin V to treat severe pneumonia, empyema, bacteremia, pericarditis, meningitis, and arthritis during the acute stage. Prophylactic uses for GU instrumentation or surgery, sigmoidoscopy, or childbirth.
Special Concerns:
More and more strains of staphylococci are resistant to penicillin V, necessitating culture and sensitivity studies.
Additional Drug Interactions:
-
Contraceptives, oral /
 Effectiveness of oral contraceptives
-
Neomycin, oral /
Absorption of penicillin V
How Supplied:
Powder for reconstitution: 125 mg/5 mL, 250 mg/5 mL;
Tablet: 250 mg, 500 mg
Dosage
?Oral Solution, Tablets
Streptococcal infections, including scarlet fever and mild erysipelas.
Adults and children over 12 years: 125-250 mg q 6-8 hr for 10 days.
Children, usual: 500 mg q 8 hr for pharyngitis.
Staphylococcal infections (including skin and soft tissue), fusospirochetosis of oropharynx.
Adults and children over 12 years: 250 mg q 6-8 hr.
Pneumococcal infections, including otitis media.
Adults and children over 12 years: 250 mg q 6 hr until afebrile for at least 2 days.
Prophylaxis of recurrence of rheumatic fever/chorea.
Adults and children over 12 years:125-250 mg b.i.d., on a continuing basis.
Prophylaxis of septicemia caused by
Staphylococcus pneumoniae in children with sickle cell anemia.
125 mg b.i.d.
Anaerobic infections.
250 mg q.i.d. See also
Penicillin G, Procaine, Aqueous, Sterile
[.
]
Lyme disease.
250-500 mg q.i.d. for 10-20 days (for children less than 2 years of age, 50 mg/kg/day in four divided doses for 10-20 days).
NOTE: 250 mg penicillin V is equivalent to 400,000 units. |
