[.
]
Action/Kinetics:
Semisynthetic opiate causing mild sedation and little or no antitussive effect. Most effective in relieving acute pain.
Onset: 15-30 min.
Peak effect: 60 min.
Duration: 4-6 hr.
t
1/2: 3.2 hr for immediate-release product and 4.5 hr for extended-release. Dependence liability is moderate. Oxycodone terephthalate is available but only in combination with aspirin (e.g., Percodan) or acetaminophen.
Uses:
Moderate to severe pain. The extended-release product (OxyContin) is indicated for moderate to severe pain, including that due to cancer, injuries, arthritis, lower back problems, and other musculoskeletal conditions that require treatment for more than a few days.
NOTE: The 80 mg extended-release tablet is only for use in opiate-dependent clients.
Additional Contraindications:
Use in hypercarbia, paralytic ileus, children or during labor. Clients with gastric distress, such as colitis or gastric or duodenal ulcer, and clients who have glaucoma should not receive Percodan, which also contains aspirin.
Special Concerns:
OxyContin 80 mg controlled release is indicated only for opiate-tolerant clients.
Additional Drug Interactions:
Use with protease inhibitors
CNS and respiratory depression.
How Supplied:
Capsule: 5 mg;
Solution, Concentrate: 20 mg/mL;
Solution, Oral: 5 mg/5 mL;
Tablet: 5 mg;
Tablet, Extended Release: 10 mg, 20 mg, 40 mg, 80 mg
Dosage
?Capsule, Oral Concentrate, Oral Solution, Tablet, Controlled Release Tablet
Analgesia.
Adults: 10-30 mg q 4 hr (5 mg q 6 hr for OxyIR and OxyFAST, as needed). Individualize dose.
