Mupirocin
Mupirocin (Bactroban)
Mupirocin
(myou- PEER-oh-sin)
Pregnancy Category: B Bactroban (Rx)
Mupirocin Calcium
Mupirocin
Pregnancy Category: B Bactroban Cream Bactroban Nasal (Rx)

Classification: Anti-infective, topical

Action/Kinetics: Binds to bacterial isoleucyl transfer RNA synthetase, which results in inhibition of protein synthesis by the organism. Not absorbed into the systemic circulation. Serum present in exudative wounds decreases the antibacterial activity. Metabolized to the inactive monic acid in the skin which is removed by normal skin desquamation. No cross resistance with other antibiotics such as chloramphenicol, erythromycin, gentamicin, lincomycin, methicillin, neomycin, novobiocin, penicillin, streptomycin, or tetracyclines.

Uses: Topical: To treat impetigo and secondarily infected traumatic skin lesions due to Staphylococcus aureus, Streptococcus pyogenes and beta-hemolytic streptococcus. Nasal: Eradication of nasal colonization with methicillin-resistant S. aureus in adult clients and health care workers.

Contraindications: Ophthalmic use. Lactation. Use if absorption of large quantities of polyethylene glycol is possible (i.e., large, open wounds). Use with other nasal products.

Special Concerns: Superinfection may result from chronic use. Safety and efficacy have not been established in children for mupirocin nasal.

Side Effects: Topical use: Superinfection, rash, burning, stinging, pain, nausea, tenderness, erythema, swelling, dry skin, contact dermatitis, and increased exudate.
Nasal use: Headache, rhinitis, respiratory disorder (including upper respiratory tract congestion), pharyngitis, taste perversion, burning, stinging, cough, pruritus, blepharitis, diarrhea, dry mouth, ear pain, epistaxis, nausea, rash.

How Supplied: Nasal Ointment: 2%; Ointment: 2%; Topical Cream: 2%

Dosage
?Topical Cream
Apply to affected area t.i.d. for 10 days.
?Topical Ointment
Children, over 2 months of age: A small amount of ointment is applied to the affected area t.i.d. If no response is seen after 3-5 days, the client should be reevaluated.
?Nasal Ointment
Divide about one-half of the ointment from the single-use tube between the nostrils and apply in the morning and evening for 5 days.