Minocycline hydrochloride
Minocycline hydrochloride (Minocin)
Minocycline hydrochloride
(mih-no- SYE-kleen)
Pregnancy Category: D Alti-Minocycline Apo-Minocycline Gen-Minocycline Dynacin Minocin Novo-Minocycline Vectrin (Rx)

Classification: Antibiotic, tetracycline

See Also: See also Anti-Infectives and Tetracyclines.

Action/Kinetics: In fasting adults, 90% to 100% of an oral dose is absorbed. Peak plasma levels: 1-4 hr. Absorption is less affected by milk or food than for other tetracyclines. t 1/2, elimination: 11-26 hr. Metabolized in the liver.

Uses: See also Tetracyclines. To eliminate meningococci from the nasopharynx of asymptomatic Neisseria meningitidis carriers in which the risk of meningococcal meningitis is high. Note: Due to adverse CNS effects, use rifampin to treat meningococcus carriers when the drug susceptibility is not known or when the organism is sulfa-resistant. Use minocycline only when rifampin is contraindicated.
(1) Granulomas of the skin caused by Mycobacterium marinum. (2) In combination with gonococcal regimens for presumptive treatment of coexisting chlamydial infections. (3) Uncomplicated gonogoccal urethritis in adult males. (4) Treatment of uncomplicated urethral, endocervical, or rectal infections cau sed by Chlamydia trachomatis or Ureaplasma urealyticum in adults. (5) Intrapleurally as a sclerosing agent to control pleural effusions assocated with metastatic tumors. (6) Treatment of cholera and nocardiosis. (7) Adjunctive treatment of inflammatory acne unresponsive to oral tetracycline HCl or oral erythromycin.

Additional Side Effects Blue-gray pigmentation areas of cutaneous inflammation, vertigo, ataxia, drowsiness, Stevens-Johnson syndrome (rare).

How Supplied: Capsules: 50 mg, 100 mg; Powder for Injection: 100 mg; Syrup: 50 mg/5 mL; Tablets: 100 mg.

Dosage
?Capsules, Injection, Suspension, Tablets Infections against which effective, including asymptomatic meningococcus carriers.
Adults, initial: 200 mg; then 100 mg q 12 hr. An alternative regimen is 100-200 mg initially followed by 50 mg q 6 hr. The length of treatment is 5 days for meningococcus carriers. Children over 8 years of age, initial: 4 mg/kg; then 2 mg/kg q 12 hr.
Mycobacterial infections.
100 mg PO b.i.d. for 6-8 weeks.
Uncomplicated gongococcal urethritis in adult males.
100 mg b.i.d. for 5 days.
Uncomplicated urethral, endocervical, or rectal infections due to Chlamydia trachomatis or Ureaplasma urealyticum.
100 mg PO b.i.d. for at least 7 days.
Nongonococcal urethritis caused by C. trachomatis or Mycoplasma.
100/day PO in 1 or 2 divided doses for 1 to 3 weeks.
Sclerosing agent to control pleural effusions associated with metastatic cancer.
300 mg diluted with 40-50 mL of 0.9% NaCl injection and instilled into the pleural space through a thoracostomy tube.
Cholera in conjunction with fluid and electrolyte replacement.
Initial: 200 mg PO; then 100 mg PO 12 hr for 48-72 hr.
Adjunct to treat inflammatory acne unresponsive to PO tetracycline HCl or erythromycin.
50 mg PO 1-3 times/day.