Action/Kinetics:
Mixture of synthetic levothyroxine sodium (T
4) and liothyronine (T
3) in a 4:1 ratio by weight and in a 1:1 ratio by biologic activity.
Dosage ?TabletsHypothyroidism. Adults and children, initial: 50 mcg levothyroxine and 12.5 mcg liothyronine (Thyrolar);
then, at monthly intervals, increments of like amounts can be made until the desired effect is achieved.
Usual maintenance: 50-100 mcg of levothyroxine and 12.5-25 mcg liothyronine daily.
Congenital hypothyroidism. Children, 0-6 months: 8-10 mcg T
4/kg/day (25-50 mcg/day);
6-12 months: 6-8 mcg T
4/kg/day (50-75 mcg/day);
1-5 years: 5-6 mcg T
4/kg/day (75-100 mcg/day);
6-12 years: 4-5 mcg T
4/kg/day (100-150 mcg/day);
over 12 years: 2-3 mcg T
4/kg/day (over 150 mcg/day).