Levamisole hydrochloride

Home > Drug Prescribing Database > L > Levamisole hydrochloride

Questions | Reviews

N/A

suffering for the last 7 years from stomach acidity, fishers, swelling in rectum & anus as well as bubbles, resulting in stool passing problem particularly when stool is in deform. Stool is made possible to pass with the help of finger to make passage...
by Syed Muzzammil Hussain in Rawalpindi, Punjab, Pakistan., 01/19/2016

is there any interaction between levamisole hydrochloride and phloxin b (color)?

question: is there any interaction between levamisole hydrochloride and phloxin b(color). the color of the outer surface of the tablet is fading when exposed to strong sunlight.
by girish in india, 11/25/2005

Levamisole hydrochloride
Levamisole hydrochloride (Ergamisol)
Levamisole hydrochloride
(lee- VAM-ih-sohl)
Pregnancy Category: C Ergamisol Novo-Levamisole (Rx)

Classification: Antineoplastic, adjunct

Action/Kinetics: Used in combination with fluorouracil; considered to be an immunomodulator. It restores depressed immune function. As such, it stimulates formation of antibodies, stimulates T-cell activation and proliferation, potentiates monocyte and macrophage function (including phagocytosis and chemotaxis), and increases mobility adherence and chemotaxis of neutrophils. Rapidly absorbed from the GI tract. Peak plasma levels: 0.13 mcg/mL after 1.5-2 hr. t 1/2: 3-4 hr. Metabolized by the liver and excreted mainly in the urine.

Uses: In combination with fluorouracil to treat clients with Dukes' stage C colon cancer following surgical resection.

Contraindications: Lactation.

Special Concerns: Safety and effectiveness have not been demonstrated in children. Agranulocytosis, caused by levamisole, may be accompanied by a flu-like syndrome, or it may be asymptomatic. Thus, hematologic monitoring is required.

Side Effects: GI: Commonly nausea and diarrhea; vomiting, stomatitis, anorexia, abdominal pain, constipation, flatulence, dyspepsia. Hematologic: Leukopenia, thrombocytopenia, anemia, granulocytopenia. Dermatologic: Commonly: dermatitis and pruritus; alopecia, skin discoloration. CNS: Dizziness, headache, inability to concentrate, weakness, memory loss, paresthesia, ataxia, somnolence, depression, insomnia, confusion, nervousness, anxiety, forgetfulness. Musculoskeletal: Arthralgia, myalgia. Ophthalmologic: Abnormal tearing, conjunctivitis, blurred vision. Miscellaneous: Fatigue, fever, rigors, chest pain, edema, taste perversion, altered sense of smell, infection, hyperbilirubinemia, epistaxis.

Drug Interactions: Ethanol / Disulfiram-like reaction when used with levamisole Phenytoin / Phenytoin plasma levels

How Supplied: Tablet: 50 mg

Dosage
?Tablets
Adults, initial: Levamisole, 50 mg q 8 hr for 3 days (starting 7-30 days after surgery) given together with fluorouracil, 450 mg/m ²/day by IV push for 5 days (starting 21-34 days after surgery). Maintenance: Levamisole, 50 mg q 8 hr for 3 days q 2 weeks for 1 year; fluorouracil, 450 mg/m ²/day by IV push once a week beginning 28 days after the beginning of the 5-day course and continuing for 1 year.