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Action/Kinetics:
Hydromorphone is 7-10 times more analgesic than morphine, with a shorter duration of action. It manifests less sedation, less vomiting, and less nausea than morphine, although it induces pronounced respiratory depression.
Onset: 15-30 min.
Peak effect: 30-60 min.
Duration: 4-5 hr.
t
1/2: 2-3 hr. Give rectally for prolonged activity.
Uses:
Analgesia for moderate to severe pain (e.g., surgery, cancer, biliary colic, burns, renal colic, MI, bone trauma). Dilaudid-HP is a concentrated solution intended for those tolerant to narcotics.
Additional Contraindications:
Migraine headaches. Use in children or during labor. Status asthmaticus, obstetrics, respiratory depression in absence of resuscitative equipment. Lactation.
Special Concerns:
Do not confuse Dilaudid-HP with standard parenteral solutions of Dilaudid or with other narcotics as overdose and death can result. Use Dilaudid-HP with caution in clients with circulatory shock.
Additional Side Effects:
Nystagmus.
Additional Drug Interactions:
CNS and respiratory depression when used with protease inhibitors.
How Supplied:
Injection: 1 mg/mL, 2 mg/mL, 4 mg/mL, 10 mg/mL;
Liquid, Oral: 1 mg/mL;
Powder for injection, lyophilized: 250 mg/vial;
Suppository; 3 mg;
Tablet: 1 mg, 2 mg, 3 mg, 4 mg, 8 mg
Dosage
?Liquid
Analgesia.
Adults: 2.5-10 mg q 4-6 hr as necessary.
?Suppositories
Analgesia.
Adults: 3 mg q 6-8 hr or as directed by physician.
?Tablets
Analgesia.
Adults: 2-4 mg q 4-6 hr; for more severe pain, 4 or more mg q 4-6 hr.
?SC, IM, IV
Analgesia.
Adults: 1-2 mg IM or SC q 4-6 hr. For severe pain, 3-4 mg q 4-6 hr. May be given by slow IV over 2-3 min.
