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Action/Kinetics:
Also has mild diuretic effects.
Onset: 1- 3 hr.
t
1/2: 2-4 hr.
Duration: 10-24 hr. Metabolized in liver to inactive metabolites, which are excreted through the kidneys.
Uses:
Adjunct to diet for control of hyperglycemia in clients with non-insulin-dependent diabetes.
Additional Drug Interactions:
Cimetidine may
effect of glipizide due to
breakdown by liver.
How Supplied:
Tablet: 5 mg, 10 mg;
Tablet, Extended Release: 5 mg, 10 mg
Dosage
?Tablets, Immediate Release
Diabetes.
Adults, initial: 5 mg 30 min before breakfast;
then, adjust dosage by 2.5-5 mg every few days, depending on the blood glucose response, until adequate control is achieved.
Maintenance: 15-40 mg/day. Older clients should begin with 2.5 mg.
?Tablets, Extended Release
Diabetes.
Adults, initial: 5 mg with breakfast. Monitor response to therapy by measuring HbA1c at 3-month intervals. Dose can be increased to 10 mg if response is inadequate.
Maintenance: 5 or 10 mg once daily; some may require 20 mg/day (maximum).
