Follitropin alfa, Follitropin beta
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Classification:
Ovarian stimulant, gonadotropin
Action/Kinetics:
Both products are human FSH prepared by recombinant DNA technology. When given with HCG, products stimulate ovarian follicular growth in women who do not have primary ovarian failure. Steady state plasma levels reached within 4 to 5 days. Increased body weight or body mass index (BMI) results in a decrease in rate of absorption. Increased risk of multiple births.
Uses:
Induction of ovulation and pregnancy in anovulatory infertile clients where cause of infertility is functional. To stimulate development of multiple follicles in ovulatory clients undergoing in-vitro fertilization.
Contraindications:
Use in primary ovarian failure; uncontrolled thyroid or adrenal dysfunction; in presence of any cause of infertility other than anovulation; tumor of ovary, breast, uterus, hypothalamus, or pituitary gland; abnormal vaginal bleeding of undetermined origin; ovarian cysts or enlargement not due to polycystic ovary syndrome; pregnancy; use in children; hypersensitivity to products.
Special Concerns:
Use with caution during lactation.
Side Effects:
CV: Intravascular thrombosis and embolism causing venous thrombophlebitis,
pulmonary embolism pulmonary infarction, stroke, arterial occlusion (leading to loss of limb).
Pulmonary: Atelectasis, ARDS, exacerbation of asthma.
Ovarian hyperstimulation syndrome: Ovarian enlargement, abdominal pain/distention, N&V;, diarrhea, dyspnea, oliguria, ascites, pleural effusion, hypovolemia, electrolyte imbalance, hemoperitoneum, thromboembolic events.
Hypersensitivity: Febrile reaction, chills, musculoskeletal aches, joint pains, malaise, headache, fatigue.
GI: N&V;, diarrhea, abdominal cramps, bloating.
Dermatologic: Dry skin, body rash, hair loss, hives.
Miscellaneous: Ovarian cysts, pain, swelling, headache, irritation at site of injection, breast tenderness.
How Supplied:
Follitropin alfa:
Powder for injection: 75 IU, 150. IU; Follitropin beta:
Powder for injection: 75 IU
Dosage
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