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Flutamide
Flutamide (Eulexin)
Flutamide
(
FLOO-tah-myd)
Pregnancy Category: D
Euflex
Novo-Flutamide
PMS-Flutamide
Eulexin
(Rx)
Classification:
Antineoplastic, hormonal agent
See Also:
See also
Antineoplastic Agents
[.
]
Action/Kinetics:
Acts either to inhibit uptake of androgen or to inhibit nuclear binding of androgen in target tissues. Thus, the effect of androgen is decreased in androgen-sensitive tissues. Rapidly metabolized to active (þ-hydroxylated derivative) and inactive metabolites in the liver and mainly excreted in the urine.
t
1/2 of active metabolite: 6 hr (8 hr in geriatric clients). Ninety-four percent to 96% is bound to plasma proteins.
Uses:
In combination with leuprolide acetate (i.e., a LHRH agonist) to treat stage D
2 metastatic prostatic carcinoma as well as locally confined stage B
2-C prostate cancer. In combination with goserelin acetate depots (Zoladex) to treat locally confined early stage B
2-C prostate cancer before and during radiation therapy.
Contraindications:
Use during pregnancy or if basline serum ALT values exceed twice ULN.
Side Effects:
Side effects are listed for treatment of flutamide with LHRH agonist.
GU: Loss of libido, impotence.
CV: Hot flashes, hypertension.
GI: N&V;, diarrhea, GI disturbances, anorexia.
CNS: Confusion, depression, drowsiness, anxiety, nervousness.
Hematologic: Anemia, leukopenia, thrombocytopenia,
hemolytic anemia macrocytic anemia, methemoglobinemia.
Hepatic: Hepatitis, cholestatic jaundice, hepatic encephalopathy, jaundice,
hepatic necrosis, liver failure.
Dermatologic: Rash, injection site irritation, erythema, ulceration, bullous eruptions,
epidermal necrolysis.
Miscellaneous: Gynecomastia, edema, neuromuscular symptoms, pulmonary symptoms, GU symptoms, malignant breast tumors.
Laboratory Test Alterations:
 AST, ALT, serum creatinine, SGGT, BUN, bilirubin.
Overdose Management:
Symptoms: Breast tenderness, gynecomastia, increases in AST. Also possible are ataxia, anorexia, vomiting, decreased respiration, lacrimation, sedation, hypoactivity, and piloerection.
Treatment: Induce vomiting if client is alert. Frequently monitor VS and observe closely.
How Supplied:
Capsule: 125 mg
Dosage
?Capsules
Locally confined stage B
2-C and stage D
2 metastatic cancer of the prostate.
250 mg (2 capsules) t.i.d. q 8 hr for a total daily dose of 750 mg. |
