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Fluphenazine decanoate
Fluphenazine decanoate (Modecate Decanoate
 , Modecate Concentrate
, Prolixin Decanoate)
Fluphenazine
(flew-
FEN-ah-zeen)
Modecate Concentrate
Modecate Decanoate
PMS-Fluphenazine
Prolixin Decanoate
Rho-Fluphenazine Decanoate
(Rx)
Fluphenazine enanthate
Fluphenazine enanthate (Moditen Enanthate
, Prolixin Enanthate)
Fluphenazine
(flew-
FEN-ah-zeen)
Moditen Enanthate
Prolixin Enanthate
(Rx)
Fluphenazine hydrochloride
Fluphenazine hydrochloride (Prolixin)
Fluphenazine
(flew-
FEN-ah-zeen)
Apo-Fluphenazine
Permitil
Prolixin
Moditen HCl
PMS-Fluphenazine
(Rx)
Classification:
Antipsychotic, piperazine-type phenothiazine
See Also:
See also
Antipsychotic Agents, Phenothiazines
[.
]
Action/Kinetics:
High incidence of extrapyramidal symptoms and a low incidence of sedation, anticholinergic effects, antiemetic effects, and orthostatic hypotension. The enanthate and decanoate esters dramatically increase the duration of action.
Decanoate:
Onset, 24-72 hr;
peak plasma levels, 24-48 hr;
t
1/2 (approximate), 14 days;
duration, up to 4 weeks.
Enanthate:
Onset, 24-72 hr;
peak plasma levels, 48-72 hr;
t
1/2 (approximate), 3.6 days;
duration, 1-3 weeks.
Fluphenazine hydrochloride can be cautiously administered to clients with known hypersensitivity to other
phenothiazines. Fluphenazine enanthate may replace fluphenazine hydrochloride if desired response occurs with hypersensitivity reaction to fluphenazine.
Uses:
Psychotic disorders. Adjunct to tricyclic antidepressants for chronic pain states (e.g., diabetic neuropathy, and clients trying to withdraw from narcotics).
How Supplied:
Fluphenazine decanoate:
Injection: 25 mg/mL
Fluphenazine enanthate:
Injection: 25 mg/mL
Fluphenazine hydrochloride:
Elixir: 2.5 mg/5 mL;
Injection: 2.5 mg/mL;
Tablet: 1 mg, 2.5 mg, 5 mg, 10 mg
Dosage
Fluphenazine hydrochloride is administered
PO and IM. Fluphenazine enanthate or decanoate are administered
SC and IM.
Hydrochloride.
?Elixir, Oral Solution, Tablets
Psychotic disorders.
Adults and adolescents, initial: 0.5-10 mg/day in divided doses q 6-8 hr;
then, reduce gradually to maintenance dose of 1-5 mg/day (usually given as a single dose, not to exceed 20 mg/day).
Geriatric, emaciated, debilitated clients, initial: 1-2.5 mg/day;
then, dosage determined by response.
Pediatric: 0.25-0.75 mg 1-4 times/day.
Hydrochloride.
?IM
Psychotic disorders.
Adults and adolescents: 1.25-2.5 mg q 6-8 hr as needed. Maximum daily dose: 10 mg. Elderly, debilitated, or emaciated clients should start with 1-2.5 mg/day.
Decanoate.
?IM, SC
Psychotic disorders.
Adults, initial: 12.5-25 mg;
then, the dose may be repeated or increased q 1-3 weeks. The usual maintenance dose is 50 mg/1-4 weeks. Maximum adult dose: 100 mg/dose.
Pediatric, 12 years and older: 6.25-18.75 mg/week; the dose can be increased to 12.5-25 mg given q 1-3 weeks.
Pediatric, 5-12 years: 3.125-12.5 mg with this dose being repeated q 1-3 weeks.
Enanthate.
?IM, SC
Psychotic disorders.
Adults and adolescents: 12.5-25 mg; dose can be repeated or increased q 1-3 weeks. For doses greater than 50 mg, increases should be made in increments of 12.5 mg. Maximum adult dose: 100 mg. |
