Fenoldopam mesylate
Fenoldopam mesylate (Corlopam)
Fenoldopam mesylate
(feh- NOL-doh-pam)
Pregnancy Category: B Corlopam (Rx)

Classification: Drug for hypertensive emergency

Action/Kinetics: Rapid-acting vasodilator that is an agonist for D ₁-like dopamine receptors and þ ₂-adrenoreceptors. Causes vasodilation in coronary, renal, mesenteric, and peripheral arteries; vascular beds do not respond uniformly. t 1/2, elimination: About 5 min in mild to moderate hypertensives. Steady-state levels: About 20 min. Metabolized in liver and most is excreted in urine.

Uses: Hypertensive emergencies.

Contraindications: Use with beta-blockers or in those with sulfite sensitivity.

Special Concerns: Use with caution during lacatation and in those with glaucoma or intraocular hypertension. Safety and efficacy have not been determined in children.

Side Effects: CV:
Tachycardia, hypotension, flushing, ST-T abnormalities, postural hypotension, extrasystoles, palpitations, bradycardia, heart failure, ischemic heart disease, MI angina pectoris. Body as a whole: Headache, sweating, back pain, non-specific chest pain, pyrexia, limb cramp. CNS: Nervousness, anxiety, insomnia, dizziness. GI: N&V;, abdominal pain or fullness, constipation, diarrhea. Respiratory: Nasal congestion, dyspnea, upper respiratory disorder. Hematologic: Leukocytosis, bleeding. Miscellaneous: Reaction at injection site, urinary tract infection, oliguria.

Laboratory Test Alterations: Creatinine, BUN, serum glucose, transaminase, LDH. Hypokalemia.

How Supplied: Injection concentrate: 10 mg/mL

Dosage
?Constant IV infusion Hypertensive emergency.
Rate of infusion is individualized according to body weight and to desired speed and extent of effect. See package insert for table of infusion rates. Doses range from 0.025 mcg/kg/min-0.3 mcg/kg/min for a body weight of 40 kg to 0.094 mcg/kg/min-1.13mcg/kg/min for a body weight of 150 kg.