Factor IX Complex (Human)
Factor IX Complex (Human)
Factor IX Complex (Human)
( FAK-tor 9)
Pregnancy Category: C AlphaNine SD Benefix Konyne 80 Hemonyne Mononine Profilnine SD Proplex T (Rx)

Classification: Hemostatic, systemic

Action/Kinetics: Causes an increase in factor IX levels, thus minimizing hemorrhage in those with factor IX deficiency. Factors II, VII, and X may also be increased. t 1/2: 22 hr. The mean increase in circulating factor IX after IV infusion is 0.67-1.15 IU/dL rise per IU/kg body weight.

Uses: To prevent or control bleeding in clients with factor IX deficiency, especially hemophilia B and Christmas disease. Factor VII deficiency (Proplex T only). Hemophilia A with inhibitors to factor VIII.

Contraindications: Factor VII deficiency, except for Proplex T. Use when fresh frozen plasma is effective. Liver disease with suspected intravascular coagulation or fibrinolysis. Hypersensitivity to mouse proteins.

Special Concerns: Assess benefit versus risk prior to use in liver disease or elective surgery.

Side Effects: CV: DIC, thrombosis. High doses may cause MI, venous or pulmonary thrombosis. Miscellaneous: Chills, fever. Symptoms due to rapid infusion: N&V;, headache, fever, chills, tingling, flushing, urticaria, and changes in BP or pulse rate. Most of these side effects disappear when rate of administration is slowed.  The preparation also contains trace amounts of blood groups A and B and isohemagglutinins, which may cause intravascular hemolysis when administered in large amounts to clients with blood groups A, B, and AB.  Although careful screening is undertaken, both hepatitis and AIDS may be transmitted using factor IX Complex since it is derived from pooled human plasma.

Drug Interactions: Risk of thrombosis if administered with aminocaproic acid.

How Supplied: Powder for injection

Dosage
?IV Factor IX deficiency.
Individualized, depending on severity of bleeding, degree of deficiency, body weight, and level of factor required. Minimum factor IX level required in surgery or following trauma is 25% of normal, which is maintained for 1 week after surgery. As a guide in determining the units required to raise blood level percentages of factor IX, use the following formula for human-derived factor IX:
1 unit/kg x body weight (kg) x desired increase (% of normal).
For recombinant factor IX, use the following formula:
1.2 IU/kg x body weight (kg) x desired increase (% of control).
Factor VII deficiency (Proplex T only).
To determine the units needed to raise blood level percentages, use the following:
0.5 unit/kg x body weight (kg) x desired increase (% of normal). The dose may be repeated q 4-6 hr. The package insert should be checked carefully as a guideline for doses for various factor deficiencies.
Factor VII deficiency (hemophilia A) -- Proplex T or Konyne 80 only.
Use dosage levels approximating 75 IU/kg.
Bleeding in hemophilia A with factor VIII inhibitors.
75 IU/kg.