[.
]
Action/Kinetics:
Available as both the potassium (immediate-release) and sodium (delayed-release) salts.
Immediate-release product.
Onset: 30 min.
Peak plasma levels: 1 hr.
Duration: 8 hr.
Delayed-release product.
Peak plasma levels: 2-3 hr.
t
1/2: 1-2 hr. For all dosage forms, food will affect the rate, but not the amount, absorbed from the GI tract. Metabolized in the liver and excreted by the kidneys.
Uses:
PO, Immediate-release: Analgesic, primary dysmenorrhea.
PO, Immediate- or Delayed-release: Rheumatoid arthritis, osteoarthritis, ankylosing spondylitis.
PO, Delayed-release: Osteoarthritis, rheumatoid arthritis.
Investigational: Mild to moderate pain, juvenile rheumatoid arthritis, acute painful shoulder, sunburn.
Ophthalmic: Postoperative inflammation following cataract or corneal refractive surgery.
Contraindications:
Wearers of soft contact lenses.
Special Concerns:
Use with caution during lactation. Safety and effectiveness have not been determined in children. When used ophthalmically, may cause increased bleeding of ocular tissues in conjunction with ocular surgery. Healing may be slowed or delayed.
Side Effects:
Following ophthalmic use: Keratitis, increased intraocular pressure, ocular allergy, N&V;, anterior chamber reaction, viral infections, transient burning and stinging on administration. When used with soft contact lenses, may cause ocular irritation, including redness and burning.
How Supplied:
Diclofenac potassium:
Tablet: 50 mg
Diclofenac sodium:
Enteric Coated Tablet: 25 mg, 50 mg, 75 mg;
Ophthalmic
solution: 0.1%;
Tablet, Extended Release: 100 mg
Dosage
?Immediate-Release Tablets, Delayed-Release Tablets
Analgesia, primary dysmenorrhea.
Adults: 50 mg t.i.d. of immediate-release tablets. In some, an initial dose of 100 mg followed by 50-mg doses may achieve better results. After the first day, the total daily dose should not exceed 150 mg.
Rheumatoid arthritis.
Adults: 100-200 mg/day in divided doses (e.g., 50 mg t.i.d. or q.i.d.; 75 mg b.i.d. of the sodium salt). For chronic therapy, use extended-release tablets, 100 mg once or twice daily, not to exceed 225 mg/day.
Osteoarthritis.
Adults: 100-150 mg/day in divided doses (e.g., 50 mg b.i.d. or t.i.d.; 75 mg b.i.d. of the sodium salt). For chronic therapy, use extended-release tablets, 100 mg/day. Doses greater than 200 mg/day have not been evaluated.
Ankylosing spondylitis.
Adults: 25 mg q.i.d. with an extra 25-mg dose at bedtime, if necessary. Doses greater than 125 mg/day have not been evaluated.
?Ophthalmic Solution, 0.1%
Following cataract surgery.
1 gtt in the affected eye q.i.d. beginning 24 hr after cataract surgery and for 2 weeks thereafter.
Corneal refractive surgery.
1-2 gtt within 1 hr prior to surgery; then, apply 1-2 gtt within 15 min of surgery and continue q.i.d. for three days or less.
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