Cholestyramine resin
Questions | Reviews
prevalite
What is the purpose of prevalite? Does it ease diarreah or is it for constipatio? What are the side effects? Is l packet a day a normal dose? Can it be mixed with milk products? When mixed with water, what does it taste like?
by dorothy tarantino in NY USA, 01/27/2012
Use of cholestyramine for diarhea
I have social anxiety and am taking lexapro and clonazepam. I get really bad diarhea with lexapro but its the only medication that seems to work for anxiety. Do you think it is safe to be on cholestyramine for diarhea and with these medications? Than...
by James Bishop in Iowa, 12/31/2005
Cholestyramine and Triglycerides
I would like to know the mechanism of action by which Cholestyramine produces an increase in triglycerides. I would appreciate some pharmacological details about this effect. Thanks and kind regards, Patrick
by Patrick Choueiry in Beirut, Lebanon, 12/08/2005
Classification: Hypocholesterolemic agent, bile acid sequestrant Action/Kinetics: Binds sodium cholate (bile salts) in the intestine; thus, the principal precursor of cholesterol is not absorbed due to formation of an insoluble complex, which is excreted in the feces. Decreases cholesterol and LDL and either has no effect or increases triglycerides, VLDL, and HDL. Also, itching is relieved as a result of removing irritating bile salts. The antidiarrheal effect results from the binding and removal of bile acids. Onset, to reduce plasma cholesterol: Within 24-48 hr, but levels may continue to fall for 1 yr; to relieve pruritus: 1-3 weeks; relief of diarrhea associated with bile acids: 24 hr. Cholesterol levels return to pretreatment levels 2-4 weeks after discontinuance. Fat-soluble vitamins (A, D, K) and possibly folic acid may have to be administered IM during long-term therapy because cholestyramine binds these vitamins in the intestine. Uses: Adjunct to reduce elevated serum cholesterol in primary hypercholesterolemia in those who do not respond adequately to diet. Pruritus associated with partial biliary obstruction. Diarrhea due to bile acids. Investigational: Antibiotic-induced pseudomembranous colitis (i.e., due to toxin produced by Clostridium difficile), digitalis toxicity, treatment of chlordecone (Kepone) poisoning, treatment of thyroid hormone overdose. Contraindications: Complete obstruction or atresia of bile duct. Special Concerns: Use during pregnancy only if benefits outweigh risks. Use with caution during lactation and in children. Long-term effects and efficacy in decreasing cholesterol levels in pediatric clients are not known. Geriatric clients may be more likely to manifest GI side effects as well as adverse nutritional effects. Exercise caution in phenylketonurics as Prevalite contains 14.1 mg phenylalanine per 5.5-g dose. Side Effects: GI: Constipation (may be severe), N&V;, diarrhea, heartburn, GI bleeding, anorexia, flatulence, belching, abdominal distention, abdominal pain or cramping, loose stools, indigestion, aggravation of hemorrhoids, rectal bleeding or pain, black stools, bleeding duodenal ulcer, peptic ulceration, GI irritation, dysphagia, dental bleeding, hiccoughs, sour taste, pancreatitis, diverticulitis, cholescystitis, cholelithiasis. Fecal impaction in elderly clients. Large doses may cause steatorrhea. CNS: Migraine or sinus headaches, dizziness, anxiety, vertigo, insomnia, fatigue, lightheadedness, syncope, drowsiness, femoral nerve pain, paresthesia. Hypersensitivity: Urticaria, dermatitis, asthma, wheezing, rash. Hematologic: Increased PT, ecchymosis, anemia. Musculoskeletal: Muscle or joint pain, backache, arthritis, osteoporosis. GU: Hematuria, dysuria, burnt odor to urine, diuresis. Other: Bleeding tendencies (due to hypoprothrombinemia). Deficiencies of vitamins A and D. Uveitis, weight loss or gain, osteoporosis, swollen glands, increased libido, weakness, SOB, edema, swelling of hands/feet; hyperchloremic acidosis in children, rash and irritation of the skin, tongue, and perianal area. Laboratory Test Alterations: Liver function abnormalities. Overdose Management: Symptoms: GI tract obstruction.
Drug Interactions:
How Supplied: Powder for Reconstitution: 4 g/5 g, 4 g/5.5 g, 4 g/5.7 g, 4 g/9 g
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