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Action/Kinetics:
Onset: 2-3 hr.
Peak effect: 2-6 hr.
Duration: 24-72 hr.
t
1/2: 40 hr. Bioavailability may be dose-dependent.
Additional Uses:
To potentiate and reduce dosage of other antihypertensive agents.
Special Concerns:
Geriatric clients may be more sensitive to the usual adult dose.
Additional Side Effects:
Exfoliative dermatitis, toxic epidermal necrolysis.
How Supplied:
Tablet: 15 mg, 25 mg, 50 mg, 100 mg
Dosage
?Tablets
Edema.
Adults, initial: 50-100 mg/day (30-60 mg Thalitone) or 100-200 mg (60 mg Thalitone) on alternate days. Some clients require 150 or 200 mg (90-120 mg Thalitone).
Maximum daily dose: 200 mg (120 mg Thalitone).
Pediatric: All uses, 2 mg/kg (60 mg/m
2) 3 times/week.
Hypertension.
Adults, initial: Single dose of 25 mg (15 mg Thalitone); if response is not sufficient, dose may be increased to 50 mg (30 mg Thalitone). For additional control, increase the dose to 100 mg/day (except Thalitone) or a second antihypertensive drug may be added to the regimen.
Maintenance: Determined by client response.
NOTE: Doses greater than 25 mg/day are likely to increase potassium excretion but not cause further benefit in sodium excretion or BP reduction.
