Chlorpheniramine maleate
Chlorpheniramine maleate (Chlor-Trimeton)
Chlorpheniramine maleate
(klor-fen- EAR-ah-meen)
Pregnancy Category: B Syrup Tablets Chewable Tablets: Aller-Chlor Allergy Chlo-Amine Chlor-Trimeton Allergy 4 Hour Chlor-Tripolon (OTC) Extended-release Tablets: Chlor-Trimeton 8 Hour and 12 Hour (OTC) Injectable: Chlorpheniramine maleate (Rx)

Classification: Antihistamine, alkylamine type

See Also: See also Antihistamines .

Action/Kinetics: Moderate anticholinergic and low sedative activity. Onset: 15-30 min t 1/2: 21-27 hr. Time to peak effect: 6 hr. Duration: 3-6hr.

Uses: PO: Allergic rhinitis. IM, SC: Allergic reactions to blood and plasma and adjunct to anaphylaxis therapy.

Contraindications: IV or intradermal use. Parenteral route for neonates. Use for children under 6 years of age.

Special Concerns: Geriatric clients may be more sensitive to the adult dose.

How Supplied: Capsule, Extended Release: 8 mg, 12 mg; Injection: 10 mg/mL; Syrup: 2 mg/5 mL; Tablet: 4 mg; Tablet, Extended Release: 8 mg, 12 mg, 16 mg

Dosage
?Syrup, Tablets, Chewable Tablets
Adults and children over 12 years: 4 mg q 6 hr, not to exceed 24 mg in 24 hr. Pediatric, 6-12 years: 2 mg (break 4-mg tablets in half) q 4-6 hr, not to exceed 12 mg in 24 hr. 2-6 years: 1 mg ( 1/4 of a 4-mg tablet) q 4 -6 hr.
?Extended-Release Tablets
Adults and children over 12 years: 8 mg q 8-12 hr or 12 mg q 12 hr, not to exceed 24 mg in 24 hr.
?IM, SC
Adults and children over 12 years: 5-40 mg for uncomplicated allergic reactions; 10-20 mg for amelioration of allergic reactions to blood or plasma or to treat anaphylaxis. Maximum dose per 24 hr: 40 mg.