Calcipotriene
(Calcipotriol)
Calcipotriene (Dovonex)
Calcipotriene
(kal- SIH-poh-tren)
Pregnancy Category: C Dovonex (Rx)

Classification: Topical antipsoriatic

Action/Kinetics: Synthetic vitamin D ₃ analog. Vitamin D ₃ receptors are located in skin cells known as keratinocytes. Abnormal growth and production of keratinocytes cause the scaly red patches of psoriasis. Calcipotriene regulates production and development of these skin cells. About 6% of a topically applied dose is absorbed into the systemic circulation where it is converted to inactive metabolites.

Uses: Cream, Ointment: Treatment of moderate plaque psoriasis in adults. Solution: Control moderately severe scalp psoriasis.

Contraindications: Demonstrated hypercalcemia or evidence of vitamin D toxicity. Use on the face; oral, ophthalmic, intravaginal use.

Special Concerns: Side effects are more common in geriatric clients. Use with caution during lactation. Safety and efficacy for use of topical calcipotriene in dermatoses other than psoriasis have not been studied. Safety and efficacy have not been determined in children. Children have a higher ratio of skin surface to body mass; thus, children are at a greater risk than adults of systemic side effects following use of topical medication.

Side Effects: Topical: Most commonly burning, itching, skin irritation. Also, erythema, dry skin, peeling, rash, worsening of psoriasis, dermatitis, skin atrophy, hyperpigmentation, hypercalcemia, folliculitis. Irritation of lesions and surrounding uninvolved skin. Systemic: Transient, rapidly reversible hypercalcemia.

Overdose Management: Symptoms: Hypercalcemia and other systemic effects. Treatment: Discontinue use of the medication until normal calcium levels are restored.

How Supplied: Cream: 0.005%; Ointment: 0.005%; Solution: 0.005%

Dosage
?Ointment, Cream, Solution (each 0.005%) Treatment of psoriasis.
A thin layer is applied to the affected skin b.i.d. (ointment can be used once daily) and rubbed in gently and completely.