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Action/Kinetics:
Synthetic anticholinergic. Tremor may increase as spasticity is relieved. Slight respiratory and CV effects.
Time to peak levels: 60-90 min.
Peak levels: 4-5 mcg/L.
t
1/2: About 18-24 hr. Tolerance may develop.
Uses:
Parkinsonism, especially of the postencephalitic, arteriosclerotic, and idiopathic types. Drug-induced (e.g., phenothiazines) extrapyramidal manifestations.
Additional Contraindications:
Children under the age of 3 years.
Special Concerns:
Use with caution in older children.
Additional Side Effects:
Muscle weakness, inability to move certain muscles.
How Supplied:
Tablet: 2 mg.
Dosage
?Tablets
Parkinsonism.
Adults: 2 mg t.i.d.-q.i.d., to a maximum of 16 mg/day.
Drug-induced extrapyramidal effects.
Adults: 2 mg 1-3 times/day. Maximum daily dose: 16 mg.
Adults: 2 mg; repeat q 30 min until symptoms improve, but not more than four doses daily.
Pediatric: 0.04 mg/kg (1.2 mg/m
2); repeat q 30 min until symptoms improve, but not more than four doses daily.
