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Trifluoperazine
Trifluoperazine (Stelazine)
Trifluoperazine
(try-flew-oh-PER-ah-zeen)
Pregnancy Category: C
Apo-Trifluoperazine
Novo-Trifluzine
PMS-Trifluoperazine
Stelazine
Terfluzine
(Rx)
Classification:
Antipsychotic, antiemetic, piperazine-type phenothiazine
See Also:
See also Antipsychotic Agents, Phenothiazines[.
]Action/Kinetics:
Causes a high incidence of extrapyramidal symptoms and antiemetic effects and a low incidence of sedation, orthostatic hypotension, and anticholinergic side effects. Maximum therapeutic effect: Usually 2-3 weeks after initiation of therapy.
Uses:
To manage psychotic disorders. Suitable for clients with apathy or withdrawal. Short-term treatment of nonpsychotic anxiety (not the drug of choice).
Special Concerns:
Use during pregnancy only when benefits clearly outweigh risks. Dosage has not been established in children less than 6 years of age. Geriatric, emaciated, or debilitated clients usually require a lower initial dose.
How Supplied:
Injection: 2 mg/mL; Tablet: 1 mg, 2 mg, 5 mg, 10 mg
Dosage
•Oral Solution, Tablets
Psychotic disorders.
Adults and adolescents, initial: 2-5 mg (base) b.i.d.; maintenance: 15-20 mg/day in two or three divided doses. Pediatric, 6-12 years: 1 mg (base) 1-2 times/day; adjust dose as required and tolerated.
Anxiety.
Adults and adolescents: 1-2 mg b.i.d, not to exceed 6 mg/day. Not to be given for this purpose longer than 12 weeks.
•IM
Pyschoses.
Adults: 1-2 mg q 4-6 hr, not to exceed 10 mg/day. Switch to PO therapy as soon as possible. Pediatric: Severe symptoms only: 1 mg 1-2 times/day.
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