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Trientine hydrochloride
Trientine hydrochloride (Syprine)
Trientine hydrochloride
(TRY-en-teen)
Pregnancy Category: C
Syprine
(Rx)
Classification:
Chelating agent
Action/Kinetics:
A chelating agent that binds copper, thus facilitating its excretion from the body.
Uses:
Wilson's disease (a metabolic defect resulting in excess copper accumulation) who are intolerant of penicillamine.
Contraindications:
Use in cystinuria, rheumatoid arthritis, biliary cirrhosis.
Special Concerns:
Use with caution during lactation. Safety and effectiveness in children have not been determined although the drug has been used in children as young as 6 years of age.
Side Effects:
Iron deficiency anemia, SLE.
How Supplied:
Capsule: 250 mg
Dosage
•Capsules
Wilson's disease.
Adults, initial: 750 mg/day-1.25 g/day in divided doses b.i.d., t.i.d., or q.i.d.; then, may increase to a maximum of 2 g/day. Children less than 12 years of age, initial: 500-750 mg/day in divided doses b.i.d., t.i.d., or q.i.d.; then, may increase to a maximum of 1.5 g/day. |
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