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Ticarcillin disodium and Clavulanate potassium
Ticarcillin disodium and Clavulanate potassium (Timentin)
Ticarcillin disodium/Clavulanate potassium
(tie-kar-SILL-in, klav-you-LAN-ate poe-TASS-ee-um)
Pregnancy Category: B Timentin (Rx)

Classification: Antibiotic, penicillin

See Also: See also Ticarcillin disodium and Penicillins.

Content: Each vial of the Powder for Injection and the Solution contains: ticarcillin disodium, 3.1 g, and clavulanate potassium, 0.1 g.

Action/Kinetics: Contains clavulanic acid, which protects the breakdown of ticarcillin by beta-lactamase enzymes, thus ensuring appropriate blood levels of ticarcillin.

Uses: (1) Septicemia, including bacteremia, due to ß-lactamase producing strains of Klebsiella sp., Staphylococcus aureus, and Pseudomonas aeruginosa (and other Pseudomonas species). (2) Lower respiratory tract infections due to ß-lactamase producing strains of S. aureus, Haemophilus influenzae, and Klebsiella sp. (3) Bone and joint infections due to ß-lactamase producing strains of S. aureus. (4) Skin and skin structure infections due to ß-lactamase producing strains of S. aureus, Klebsiella sp., and E. coli. (5) UTIs (complicated and uncomplicated) due to ß-lactamase producing strains of E. coli, Klebsiella sp., P. aeruginosa (and other Pseudomonas species), Citrobacter sp., Enterobacter cloacae, Serratia marcescens, and S. aureus. (6) Endometritis due to ß-lactamase producing strains of B. melaninogenicus, Enterobacter sp. (including E. cloacae), E. coli, Klebsiella pneumoniae, S. aureus, and Staphylococcus epidermidis. (7) Peritonitis due to ß-lactamase producing strains of E. coli, K. pneumoniae, and Bacteroides fragilis group.

How Supplied: See Content

Dosage
•IV Infusion Systemic and UTIs.
Adults more than 60 kg: 3.1 g (containing 0.1 g clavulanic acid) q 4-6 hr for 10-14 days. Adults less than 60 kg: 200-300 mg ticarcillin/kg/day in divided doses q 4-6 hr for 10-14 days.
Gynecologic infections.
Adults more than 60 kg, moderate infections: 200 mg/kg/day in divided doses q 6 hr; severe infections: 300 mg/kg/day in divided doses q 4 hr.
In renal insufficiency.
Initially, loading dose of 3.1 g ticarcillin and 0.1 g clavulanic acid; then, dose based on C_CR as follows. C_CR over 60 mL/min: 3.1 g q 4 hr; C_CR from 30-60 mL/min: 2 g q 4 hr; C_CR from 10&endash30; mL/min: 2 g q 8 hr; C_CR, less than 10 mL/min: 2 g q 12 hr; C_CR, less than 10 mL/min with hepatic dysfunction: 2 g q 24 hr. Clients on peritoneal dialysis: 3.1 g q 12 hr; clients on hemodialysis: 2 g q 12 hr and 3.1 g after each dialysis.