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Thioridazine hydrochloride
Thioridazine hydrochloride (Mellaril)
Thioridazine hydrochloride
(thigh-oh-RID-ah-zeen)
Pregnancy Category: C
Apo-Thioridazine
Mellaril
Mellaril-S
Novo-Ridazine
PMS-Thioridazine
Thioridazine HCl Intensol Oral
(Rx)
Classification:
Antipsychotic, piperidine-type phenothiazine
See Also:
See also Antipsychotic Agents, Phenothiazines[.
]Action/Kinetics:
High incidence of hypotension; moderate incidence of sedative and anticholinergic effects and weak antiemetic and extrapyramidal effects. May be used in clients intolerant of other phenothiazines. Peak plasma levels (after PO administration): 1-4 hr. May impair its own absorption at higher doses due to the strong anticholinergic effects. t1/2: 10 hr. Metabolized in the liver to both active and inactive metabolites.
Uses:
Management of psychotic disorders. Short-term treatment of moderate to marked depression with variable levels of anxiety in adults. Treat psychoneurotic symptoms in geriatric clients, including agitation, anxiety, depressed mood, tension, sleep disturbances, and fears.
In children: Treat severe behavioral problems marked by combativeness or explosive hyperexcitable behavior. Short-term treatment of hyperactive children showing excessive motor activity with accompanying impulsivity, short attention span, aggressivity, mood lability, and poor frustration tolerance.
Special Concerns:
Safe use during pregnancy has not been established. Dosage has not been established in children less than 2 years of age. Geriatric, emaciated, or debilitated clients usually require a lower initial dose.
Additional Side Effects:
More likely to cause pigmentary retinopathy than other phenothiazines.
How Supplied:
Oral Concentrate: 30 mg/mL, 100 mg/mL; Tablet: 10 mg, 15 mg, 25 mg, 50 mg, 100 mg, 150 mg, 200 mg
Dosage
•Oral Suspension, Oral Solution, Tablets
Psychotic disorders.
Adults, initial: 50-100 mg t.i.d. Increase gradually to a maximum of 800 mg/day, if needed to control symptoms. Then, reduce gradually to the minimum maintainence dose. Dose range: 200-800 mg/day divided into two to four doses.
Psychoneurotic symptoms.
Initial: 25 mg t.i.d. Dose range: 10 mg b.i.d.-q.i.d. in milder cases to 50 mg t.i.d. or q.i.d. Dose range: 20-200 mg/day.
Behavioral disorders in children.
Ages 2 to 12: 0.5 mg/kg/day to a maximum of 3 mg/kg/day. For moderate disorders, initially use 10 mg b.i.d.-t.i.d. For hospitalized, severely disturbed or psychotic children: 25 mg b.i.d.-t.i.d. |
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