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Tamsulosin hydrochloride
Tamsulosin hydrochloride (Flomax)
Tamsulosin hydrochloride
(tam-SOO-loh-sin)
Pregnancy Category: B
Flomax (Rx)
Classification:
Alpha-1 adrenergic blocking agent
Action/Kinetics:
Blockade of alpha-1 receptors (probably alpha1A) in prostate results in relaxation of smooth muscles in bladder neck and prostate; thus, urine flow rate is improved and there is a decrease in symptoms of BPH. Food interferes with the rate of absorption. t1/2, elimination: 5-7 hr. Significantly bound to plasma proteins. Extensively metabolized in liver; excreted through urine and feces.
Uses:
Treatment of signs and symptoms of BPH. Rule out prostatic carcinoma before using tamsulosin.
Contraindications:
Use to treat hypertension, with other alpha-adrenergic blocking agents, or in women or children.
Special Concerns:
Use with caution with concurrent administration of warfarin.
Side Effects:
Body as a whole: Headache, infection, asthenia, back pain, chest pain. CV: Postural hypotension, syncope. GI: Diarrhea, nausea, tooth disorder. CNS: Dizziness, vertigo, somnolence, insomnia, decreased libido. Respiratory: Rhinitis, pharyngitis, increased cough, sinusitis. GU: Abnormal ejaculation. Miscellaneous: Amblyopia.
Overdose Management:
Symptoms: Hypotension. Treatment: Keep client in supine position to restore BP and normalize HR. If this is inadequate, consider IV fluids. Vasopressors may also be used; monitor renal function.
Drug Interactions:
Cimetidine causes significant  in clearance of tamsulosin.
How Supplied:
Capsules: 0.4 mg
Dosage
•Capsules
Benign prostatic hypertrophy.
Adult males: 0.4 mg daily given about 30 min after same meal each day. If, after 2 to 4 weeks, clients have not responded, dose can be increased to 0.8 mg daily. |
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