| Sulindac
Sulindac (Clinoril)
Sulindac
(sul-IN-dak) Apo-Sulin Clinoril Novo-Sundac Nu-Sulindac (Rx)
Classification: Nonsteroidal
anti-inflammatory drug
See Also: See also Nonsteroidal
Anti-Inflammatory Drugs [. ]
Action/Kinetics: Biotransformed
in the liver to a sulfide, the active metabolite. Peak plasma levels of sulfide: after
fasting, 2 hr; after food, 3-4 hr. Onset, anti-inflammatory effect: within 1 week; duration,
anti-inflammatory effect: 1-2 weeks. t1/2, of sulindac: 7.8 hr; of
metabolite: 16.4 hr. Excreted in both urine and feces.
Uses: Acute and chronic
treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, acute gouty
arthritis; acute, painful shoulder; tendinitis, bursitis. Investigational: Juvenile
rheumatoid arthritis, sunburn.
Contraindications: Use with
active GI lesions or a history of recurrent GI lesions.
Special Concerns: Safety and
efficacy have not been established for children. Safe use during pregnancy has not been
established. Use with caution during lactation.
Additional Side Effects
Hypersensitivity, pancreatitis, GI pain (common), maculopapular rash. Stupor, coma
hypotension, and diminished urine output.
Additional Drug Interactions
Sulindac  effect of warfarin due to  plasma protein binding.
How Supplied: Tablet: 150
mg, 200 mg
Dosage
•Tablets Osteoarthritis, rheumatoid arthritis, ankylosing spondylitis.
Adults: 150 mg b.i.d.
Acute painful shoulder, acute gouty arthritis.
Adults: 200 mg b.i.d. for 7-14 days.
Antigout.
Adults: 200 mg b.i.d. for 7 days. |
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