| Sulfisoxazole
Sulfisoxazole
Sulfisoxazole
(sul-fih-SOX-ah-zohl)
Pregnancy Category: C Apo-Sulfisoxazole/trade> Novo-Soxazole Sulfizole (Rx)
Sulfisoxazole diolamine
Sulfisoxazole diolamine
Sulfisoxazole
(sul-fih-SOX-ah-zohl)
Pregnancy Category: C (Rx)
Classification: Sulfonamide,
short-acting
See Also: See also Sulfonamides
[. ]
Action/Kinetics: t1/2:
5.9 hr.
Uses: UTIs caused by Escherichia
coli, Klebsiella, Enterobacter, Staphylococcus aureus, Proteus mirabilis, and Proteus
vulgaris. Chancroid, inclusion conjunctivitis, adjunct in treating
chloroquine-resistant strains of Plasmodium falciparum meningitis caused by Haemophilus
influenzae, meningococcal meningitis for sulfonamide-sensitive group A strains,
nocardiosis, with penicillin to treat acute otitis media caused by H. influenzae
adjunct with pyrimethamine for toxoplasmosis in selected immunocompromised clients (e.g.,
those with AIDS, neoplastic disease, or congenital immune compromise). Ophthalmically as
an adjunct with systemic sulfonamides to treat trachoma.
Additional Contraindications Use
in infants less than 2 months of age except as adjunct with pyrimethamine to treat
congenital toxoplasmosis. Use in the presence of epithelial herpes simplex keratitis,
vaccinia, varicella, and other viral diseases of the cornea and conjunctiva. Mycobacterial
or fungal infections of the ocular structures. After uncomplicated removal of a corneal
foreign body.
Special Concerns: Safety and
efficacy of the ophthalmic products have not been established in children. Use with
caution in clients with severe dry eye.
Additional Side Effects Following
ophthalmic use: Blurred vision, itching, local irritation, epithelial keratitis,
reactive hyperemia, conjunctival edema, burning, headache or browache, transient stinging.
Additional Drug Interactions
Sulfisoxazole may  effects of
thiopental due to  plasma protein
binding.
How Supplied: Sulfisoxazole: Tablet:
500 mg. Sulfisoxazole acetyl: Suspension: 500 mg/5 mL Sulfisoxazole diolamine: Ophthalmic
Solution: 4%
Dosage
•Tablets
Adults, loading dose: 2-4 g; maintenance: 4-8 g/day in 4 to 6 divided doses,
depending on severity of the infection. Infants over 2 months, initial: 75
mg/kg/day; maintenance: 150 mg/kg/day (4 g/m2/day) in 4 to 6 divided
doses, not to exceed 6 g/day.
•Ophthalmic Solution (4%) Conjunctivitis or corneal ulcer.
1-2 gtt into conjunctival sac q 1-4 hr, depending on the severity of the infection. Dose
may be tapered by increasing the time interval between doses as the condition improves.
Trachoma.
2 qtt q 2 hr with concomitant systemic therapy. |
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