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Risedronate sodium
Risedronate sodium (Actonel)
Risedronate sodium
(rih-SEH-droh-nayt)
Pregnancy Category: C
Actonel (Rx)
Classification:
Biphosphonate for Paget's disease
Action/Kinetics:
Inhibits osteoclasts, thus leading to decreased bone resorption. Rapidly absorbed; food decreases absorption. t1/2, initial: 1.5 hr; terminal: 220 hr. Excreted unchanged in the urine.
Uses:
Treatment of Paget's disease in those who (1) have a serum alkaline phosphatase level at least two times the upper limit of normal, (2) are symptomatic, or (3) are at risk for future complications from the disease.
Contraindications:
Use in those with CCR less than 30 mL/min. Hypocalcemia. Lactation.
Special Concerns:
May cause upper GI disorders, including dysphagia, esophagitis, esophageal ulcer, or gastric ulcer. Use with caution in those with a history of UGI disorders. Safety and efficacy have not been determined in children.
Side Effects:
GI: Diarrhea, abdominal pain, nausea, constipation, belching, colitis. CNS: Headache, dizziness. Body as a whole: Flu syndrome, chest pain, asthenia, neoplasm. Musculoskeletal: Arthralgia, bone pain, leg cramps, myasthenia. Respiratory: Sinusitis, bronchitis. Ophthalmic: Amblyopia, dry eye. Miscellaneous: Peripheral edema, skin rash, tinnitus.
Overdose Management:
Symptoms: Hypocalemia. Treatment: Gastric lavage to remove unabsorbed drug. Milk or antacids to bind risedronate. IV calcium.
Drug Interactions:
- Antacids, calcium-containing /
 Absorption of risedronate
- Bone imaging agents / Risedronate interferes with these agents
- Calcium / Absorption of risedronate
- NSAIDs / Possible additive GI side effects
How Supplied:
Tablets: 30 mg
Dosage
•Tablets
Treat Paget's disease.
Adults: 30 mg once daily for 2 months. |
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