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Prochlorperazine
Prochlorperazine (Compazine)
Prochlorperazine
(proh-klor-PAIR-ah-zeen) Compazine Stemetil Suppositories (Rx)
Prochlorperazine edisylate
Prochlorperazine edisylate (Compazine Edisylate)
Prochlorperazine
(proh-klor-PAIR-ah-zeen) Compazine (Rx)
Prochlorperazine maleate
Prochlorperazine maleate (Compazine)
Prochlorperazine
(proh-klor-PAIR-ah-zeen) Compazine Stemetil (Rx)

Classification: Antipsychotic, antiemetic, piperazine-type phenothiazine

See Also: See also Antipsychotic Agents, Phenothiazines.

Action/Kinetics: Prochlorperazine causes a high incidence of extrapyramidal and antiemetic effects, moderate sedative effects, and a low incidence of anticholinergic effects and orthostatic hypotension. It also possesses significant antiemetic effects.

Uses: Psychotic disorders. Short-term treatment of generalized nonpsychotic anxiety (not drug of choice). Postoperative N&V;, radiation sickness, vomiting due to toxins. Severe N&V.; Investigational: Acute headache.

Contraindications: Use in clients who weigh less than 44 kg or who are under 2 years of age.

Special Concerns: Safe use during pregnancy has not been established. Geriatric, emaciated, and debilitated clients usually require a lower initial dose.

How Supplied: Prochlorperazine: Suppository: 2.5 mg, 5 mg, 25 mg; Prochlorperazine Edisylate: Injection: 5 mg/mL; Syrup: 5 mg/5 mL; Prochlorperazine maleate: Capsule, extended release: 10 mg, 15 mg; Tablet: 5 mg, 10 mg

Dosage
•Edisylate Syrup, Maleate Extended-Release Capsules, Tablets Psychotic disorders.
Adults and adolescents: 5 or 10 mg t.i.d. or q.i.d. for mild conditions. For severe conditions, for hospitalized, or adequately supervised clients: 10 mg t.i.d. or q.i.d. Dose can be increased gradually q 2-3 days as needed and tolerated. For extended-release capsules, up to 100-150 mg/day can be given. Pediatric, 2-12 years: 2.5 mg b.i.d.-t.i.d. Do not give more than 10 mg on the first day.
N&V.;
Adults and adolescents: 5-10 mg t.i.d.-q.i.d. (up to 40 mg/day). For extended-release capsules, the dose is 15-30 mg once daily in the morning (or 10 mg q 12 hr, up to 40 mg/day). Pediatric, 18-39 kg: 2.5 mg (base) t.i.d. (or 5 mg b.i.d.), not to exceed 15 mg/day; 14-17 kg: 2.5 mg (base) b.i.d.-t.i.d., not to exceed 10 mg/day; 9-13 kg: 2.5 mg (base) 1-2 times/day, not to exceed 7.5 mg/day. The total daily dose for children should not exceed 10 mg the first day; on subsequent days, the total daily dose should not exceed 20 mg for children 2-5 years of age or 25 mg for children 6-12 years of age.
Anxiety.
Adults and adolescents: 5 mg t.i.d.-q.i.d. on arising. Or, 15 mg sustained release on arising or 10 mg sustained release q 12 hr. Do not give more than 20 mg/day for more than 12 weeks.
•IM, Edisylate Injection Psychotic disorders, for immediate control of severely disturbed clients.
Adults and adolescents, initial: 10-20 mg; dose can be repeated q 2-4 hr as needed (usually up to three or four doses). If prolonged therapy is needed: 10-20 mg q 4-6 hr. Children, less than 12 years of age: 0.03 mg/kg by deep IM injection. After control is achieved (usually after 1 injection), switch to PO at same dosage level or higher.
N&V.;
Adults and adolescents: 5-10 mg; repeat the dose q 3-4 hr as needed. Pediatric, 2-12 years: 0.132 mg/kg.
N&V; during surgery.
Adults and adolescents: 5-10 mg (base) given as a slow injection or infusion 15-30 min before induction of anesthesia; to control symptoms during or after surgery the dose can be repeated once. The rate of infusion should not exceed 5 mg/mL/min.
•Rectal Suppositories
Pediatric, 2-12 years: 2.5 mg b.i.d.-t.i.d. with no more than 10 mg given on the first day. No more than 20 mg/day for children 2-5 years of age and 25 mg/day for children 6-12 years of age.