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Prednisone
Prednisone (Prednisone Intensol Concentrate
Prednisone
(PRED-nih-sohn)
Pregnancy Category: C
Oral Solution: Prednisone Intensol Concentrate (Rx).
Syrup: Liquid Pred (Rx).
Tablets: Alti-Prednisone
Apo-Prednisone
Deltasone
Jaa Prednisone
Meticorten
Novo-Prednisone
Orasone 1, 5, 10, 20, and 50
Panasol-S
Sterapred DS
Winpred
(Rx)
Classification:
Corticosteroid, synthetic
See Also:
See also Corticosteroids[.
]Action/Kinetics:
Three to five times as potent as cortisone or hydrocortisone. May cause moderate fluid retention. Metabolized in the liver to prednisolone, the active form.
Special Concerns:
Dose must be highly individualized.
How Supplied:
Concentrate: 5 mg/mL; Solution: 5 mg/5 mL; Syrup: 5 mg/5 mL; Tablet: 1 mg, 2.5 mg, 5 mg, 10 mg, 20 mg, 50 mg
Dosage
•Oral Concentrate, Syrup, Tablets
Acute, severe conditions.
Initial: 5-60 mg/day in four equally divided doses after meals and at bedtime. Decrease gradually by 5-10 mg q 4-5 days to establish minimum maintenance dosage (5-10 mg) or discontinue altogether until symptoms recur.
Replacement.
Pediatric: 0.1-0.15 mg/kg/day.
COPD.
30-60 mg/day for 1-2 weeks; then taper.
Ophthalmopathy due to Graves' disease.
60 mg/day; then, taper to 20 mg/day.
Duchenne's muscular dystrophy.
0.75-1.5 mg/kg/day (used to improve strength). |
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