[.
]Action/Kinetics:
May inhibit prostaglandin synthesis. Effect is comparable to that of aspirin, but with fewer GI side effects and less tinnitus. May be used with gold, corticosteroids, and antacids. Peak plasma levels: 1.5-2 mcg/mL after 3-5 hr (single dose). Steady-state plasma levels (after 7-12 days): 3-8 mcg/mL. t1/2: 50 hr. Analgesia, onset: 1 hr; duration: 2-3 days. Anti-inflammatory activity, onset: 7-12 days; duration: 2-3 weeks. Metabolites and unchanged drug excreted in urine and feces.
Uses:
Acute and chronic treatment of rheumatoid arthritis and osteoarthritis. Investigational: Juvenile rheumatoid arthritis, primary dysmenorrhea, sunburn.
Contraindications:
Safe use during pregnancy has not been determined. Use in children less than 14 years old. Lactation.
Special Concerns:
Safety and efficacy have not been established in children. Increased plasma levels and elimination half-life may be observed in geriatric clients (especially women).
Laboratory Test Alterations:
Reversible 
BUN.
How Supplied:
Capsule: 10 mg, 20 mg
Dosage
•Capsules
Anti-inflammatory, antirheumatic.
Adults: 20 mg/day in one or more divided doses. Do not assess the effect of therapy for 2 weeks.
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