[.
]Action/Kinetics:
Manifests moderate anticholinergic and sedative effects but slight orthostatic hypotensive effects. Effective plasma levels: 50-150 ng/mL. t1/2: 18-44 hr. Time to reach steady state: 4-19 days.
Uses:
Treatment of symptoms of depression. Chronic, severe neurogenic pain. Dermatologic disorders including chronic urticaria, angioedema, and nocturnal pruritus in atopic eczema.
Contraindications:
Use in children (safety and efficacy have not been determined).
Laboratory Test Alterations:
Urinary 5-HIAA.
How Supplied:
Capsule: 10 mg, 25 mg, 50 mg, 75 mg; Solution: 10 mg base/5 mL
Dosage
•Capsules, Oral Solution
Depression.
Adults: 25 mg t.i.d.-q.i.d. Dose individualized; begin at a low dosage and increase as needed. Doses above 150 mg/day are not recommended. Adolescent and elderly clients: 30-50 mg/day in divided doses or total daily dose may be given once/day.
Dermatologic disorders.
75 mg/day.
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