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Nedocromil sodium
Nedocromil sodium (Tilade)
Nedocromil sodium
(neh-DAH-kroh-mill)
Pregnancy Category: B
Mireze
Tilade
(Rx)
Classification:
Antiasthmatic
Action/Kinetics:
Inhibits the release of various mediators, such as histamine, leukotriene C4, and prostaglandin D2, from a variety of cell types associated with asthma. Has no intrinsic bronchodilator, antihistamine, or glucocorticoid activity; also, systemic bioavailability is low. t1/2: 3.3 hr. About 89% bound to plasma protein; excreted unchanged.
Uses:
Maintenance therapy in adults and children (age two and older) with mild to moderate bronchial asthma.
Contraindications:
Use for the reversal of acute bronchospasms, especially status asthmaticus.
Special Concerns:
Use with caution during lactation. Safety and efficacy have not been established in children less than 12 years of age. Has not been shown to be able to substitute for the total dose of corticosteroids.
Side Effects:
Respiratory: Coughing, pharyngitis, rhinitis, URTI, increased sputum, bronchitis, dyspnea, bronchospasm. GI tract: N&V;, dyspepsia, abdominal pain, dry mouth, diarrhea. CNS: Dizziness, dysphonia. Skin: Rash, sensation of warmth. Body as a whole: Headache, chest pain, fatigue, arthritis. Miscellaneous: Viral infection, unpleasant taste.
Laboratory Test Alterations:
 ALT.
How Supplied:
Metered dose inhaler: 1.75 mg/inh
Dosage
•Metered Dose Inhaler
Bronchial asthma.
Adults and children over 12 years of age: Two inhalations q.i.d. at regular intervals in order to provide 14 mg/day. If the client is under good control on q.i.d. dosing (i.e., requiring inhaled or oral beta agonist no more than twice a week or no worsening of symptoms occur with respiratory infections), a lower dose can be tried. In such instances, reduce the dose to 10.5 mg/day (i.e., used t.i.d.); then, after several weeks with good control, the dose can be reduced to 7 mg/day (i.e., used b.i.d.). |
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