[.
]Action/Kinetics:
Synthetic antifungal agent with a broad spectrum of activity. Thought to inhibit squalene 2,3-epoxidase, which is responsible for synthesis of sterols. The decreased levels of sterols (especially ergosterol) and the accumulation of squalene in cells result in fungicidal activity. Although used topically, approximately 6% of the drug is absorbed. Naftifine and its metabolites are excreted via the feces and urine. t1/2: 2-3 days.
Uses:
To treat tinea cruris, tinea pedis, and tinea corporis caused by Candida albicans, Epidermophyton floccosum, Microsporum canis, M. audouinii, M. gypseum, Trichophyton rubrum, T. mentagrophytes and T. tonsurans.
Contraindications:
Ophthalmic use.
Special Concerns:
Discontinue nursing while using naftifine and for several days after the last application. Safety and efficacy in children have not been determined.
Side Effects:
Topical cream: Burning, stinging, dryness, itching, local irritation, erythema. Topical gel: Burning, stinging, itching, rash, tenderness, erythema.
How Supplied:
Cream: 1%; Gel/jelly: 1%
Dosage
•Topical Cream (1%), Topical Gel (1%)
Massage into affected area and surrounding skin once daily if using the cream and twice daily (morning and evening) if using the gel.
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