[.
]Action/Kinetics:
Peak levels: 1-4 hr. t1/2: 1-3 hr for methsuximide and 36-45 hr for the active metabolite. Therapeutic serum levels: 10-40 mcg/mL.
Uses:
Treat absence seizures refractory to other drugs. May be given with other anticonvulsants when absence seizures coexist with other types of epilepsy.
Additional Side Effects:
Most common are ataxia, dizziness, and drowsiness.
Additional Drug Interactions:
Methsuximide may 
the effect of primidone.
How Supplied:
Capsule: 150 mg, 300 mg
Dosage
•Capsules
Absence seizures.
Adults and children, initial: 300 mg/day for first week; then, if necessary, increase dosage by 300 mg/day at weekly intervals until control established. Maximum daily dose: 1.2 g in divided doses.
