[.
]Action/Kinetics:
Inhibits prostaglandin synthesis. Is an anti-inflammatory, antipyretic, and analgesic. Peak plasma levels: 2-4 hr; t1/2: 2-4 hr; duration: 4-6 hr. Slowly absorbed from the GI tract, metabolized by the liver, and excreted in the urine and feces.
Uses:
Short-term relief ( < 1 week) of mild to moderate pain (e.g., pain associated with tooth extraction and musculoskeletal disorders). Primary dysmenorrhea. Investigational: PMS, sunburn.
Contraindications:
Ulceration or chronic inflammation of the GI tract, pregnancy or possibility thereof, children under 14, and hypersensitivity to the drug.
Special Concerns:
Dosage has not been established in children less than 14 years of age. Use with caution in clients with impaired renal or hepatic function, asthma, or clients on anticoagulant therapy.
Additional Side Effects:
Autoimmune hemolytic anemia if used more than 12 months. Diarrhea may be significant. Rash (maculopapular type).
Laboratory Test Alterations:
False + test for urinary bile using diazo tablets.
Drug Interactions:
- Anticoagulants /
Hypoprothrombinemia R/T 
plasma protein binding
- Insulin / Insulin requirement
- Lithium / Lithium plasma levels
How Supplied:
Capsule: 250 mg
Dosage
•Capsules
Analgesia, primary dysmenorrhea.
Adults and children over 14 years of age, initial: 500 mg; then, 250 mg q 6 hr.
