[.
]Action/Kinetics:
t1/2: 1.2 hr. Undergoes extensive first-pass metabolism. Significantly bound (greater than 98%) to plasma protein. Metabolized in the liver with 90% excreted through the feces and 5% through the urine.
Uses:
Adjunct to diet for the reduction of elevated total and LDL cholesterol levels in clients with primary hypercholesterolemia (type IIa and IIb) whose response to diet and other nondrug measures have been inadequate. The lipid-lowering effects of fluvastatin are enhanced when it is combined with a bile-acid binding resin or with niacin. Reduce triglycerides and apolipoprotein B in primary hypercholesterolemia and mixed dyslipidemia. To slow the progression of coronary atherosclerosis in
coronary heart disease.
Special Concerns:
Use with caution in clients with severe renal impairment.
Side Effects:
Side effects listed are those most common with fluvastatin. A complete list of possible side effects is provided under Antihyperlipidemic Agents--HMG-CoA Reductase Inhibitors. GI: N&V;, diarrhea, abdominal pain or cramps, constipation, flatulence, dyspepsia, tooth disorder. Musculoskeletal: Myalgia, back pain, arthralgia, arthritis. CNS: Headache, dizziness, insomnia. Respiratory: URI, rhinitis, cough, pharyngitis, sinusitis. Miscellaneous: Rash, pruritus, fatigue, influenza, allergy, accidental trauma.
Laboratory Test Alterations:
Serum transaminases.
Drug Interactions:
[.]
Additional Drug Interactions:
- Alcohol / Fluvastatin absorbed
- Digoxin /
Bioavailability of fluvastatin
- Rifampin / Fluvastatin clearance
How Supplied:
Capsule: 20 mg, 40 mg
Dosage
•Capsules
Treat primary hypercholesterolemia. Antihyperlipidemic to slow progression of coronary atherosclerosis.
Adults, initial: 20-40 mg once daily at bedtime. Dose range: 20-80 mg/day. Splitting the 80-mg dose into a twice-daily regimen results in a modest improvement in LDL cholesterol.
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