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Fluphenazine decanoate
Fluphenazine decanoate (Modecate Decanoate, Modecate Concentrate, Prolixin Decanoate)
Fluphenazine
(flew-FEN-ah-zeen) Modecate Concentrate Modecate Decanoate PMS-Fluphenazine Prolixin Decanoate Rho-Fluphenazine Decanoate (Rx)
Fluphenazine enanthate
Fluphenazine enanthate (Moditen Enanthate, Prolixin Enanthate)
Fluphenazine
(flew-FEN-ah-zeen) Moditen Enanthate Prolixin Enanthate (Rx)
Fluphenazine hydrochloride
Fluphenazine hydrochloride (Prolixin)
Fluphenazine
(flew-FEN-ah-zeen) Apo-Fluphenazine Permitil Prolixin Moditen HCl PMS-Fluphenazine (Rx)

Classification: Antipsychotic, piperazine-type phenothiazine

See Also: See also Antipsychotic Agents, Phenothiazines .

Action/Kinetics: High incidence of extrapyramidal symptoms and a low incidence of sedation, anticholinergic effects, antiemetic effects, and orthostatic hypotension. The enanthate and decanoate esters dramatically increase the duration of action. Decanoate: Onset, 24-72 hr; peak plasma levels, 24-48 hr; t1/2 (approximate), 14 days; duration, up to 4 weeks. Enanthate: Onset, 24-72 hr; peak plasma levels, 48-72 hr; t1/2 (approximate), 3.6 days; duration, 1-3 weeks.  Fluphenazine hydrochloride can be cautiously administered to clients with known hypersensitivity to other phenothiazines.  Fluphenazine enanthate may replace fluphenazine hydrochloride if desired response occurs with hypersensitivity reaction to fluphenazine.

Uses: Psychotic disorders. Adjunct to tricyclic antidepressants for chronic pain states (e.g., diabetic neuropathy, and clients trying to withdraw from narcotics).

How Supplied: Fluphenazine decanoate: Injection: 25 mg/mL Fluphenazine enanthate: Injection: 25 mg/mL Fluphenazine hydrochloride: Elixir: 2.5 mg/5 mL; Injection: 2.5 mg/mL; Tablet: 1 mg, 2.5 mg, 5 mg, 10 mg

Dosage
Fluphenazine hydrochloride is administered PO and IM. Fluphenazine enanthate or decanoate are administered SC and IM.
Hydrochloride. •Elixir, Oral Solution, Tablets Psychotic disorders.
Adults and adolescents, initial: 0.5-10 mg/day in divided doses q 6-8 hr; then, reduce gradually to maintenance dose of 1-5 mg/day (usually given as a single dose, not to exceed 20 mg/day). Geriatric, emaciated, debilitated clients, initial: 1-2.5 mg/day; then, dosage determined by response. Pediatric: 0.25-0.75 mg 1-4 times/day.
Hydrochloride. •IM Psychotic disorders.
Adults and adolescents: 1.25-2.5 mg q 6-8 hr as needed. Maximum daily dose: 10 mg. Elderly, debilitated, or emaciated clients should start with 1-2.5 mg/day.
Decanoate. •IM, SC Psychotic disorders.
Adults, initial: 12.5-25 mg; then, the dose may be repeated or increased q 1-3 weeks. The usual maintenance dose is 50 mg/1-4 weeks. Maximum adult dose: 100 mg/dose. Pediatric, 12 years and older: 6.25-18.75 mg/week; the dose can be increased to 12.5-25 mg given q 1-3 weeks. Pediatric, 5-12 years: 3.125-12.5 mg with this dose being repeated q 1-3 weeks.
Enanthate. •IM, SC Psychotic disorders.
Adults and adolescents: 12.5-25 mg; dose can be repeated or increased q 1-3 weeks. For doses greater than 50 mg, increases should be made in increments of 12.5 mg. Maximum adult dose: 100 mg.