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Dimenhydrinate
Dimenhydrinate (Dramamine)
Dimenhydrinate
(dye-men-HY-drih-nayt)
Pregnancy Category: B Oral Liquid Syrup Tablets Chewable Tablets: Apo-Dimenhydrinate Calm-X Dimentabs Dramamine Gravol Marmine Motion-Aid PMS-Dimenhydrinate Travamine Travel Tabs Traveltabs Triptone (OTC). Injection: Dimenhydrinate Injection Dinate Dramanate Dramilin Dymenate Gravol Hydrate Marmine Reidamine (Rx)

Classification: Antihistamine, antiemetic

See Also: See also Antihistamines and Antiemetics.

Action/Kinetics: Contains both diphenhydramine and chlorotheophylline. Antiemetic mechanism not known, but it does depress labyrinthine and vestibular function. May mask ototoxicity due to aminoglycosides. Possesses anticholinergic activity. Duration: 3-6 hr.

Uses: Motion sickness, especially to relieve nausea, vomiting, or dizziness. Treat vertigo.

Special Concerns: Use of the injectable form is not recommended in neonates. Geriatric clients may be more sensitive to the usual adult dose.

How Supplied: Chew Tablet: 50 mg; Injection: 50 mg/mL; Liquid: 12.5 mg/4 mL, 12.5 mg/5 mL; Tablet: 25 mg, 50 mg

Dosage
•Elixir, Syrup, Tablets, Chewable Tablets Motion sickness.
Adults: 50-100 mg q 4 hr, not to exceed 400 mg/day. Pediatric, 6-12 years: 25-50 mg q 6-8 hr, not to exceed 150 mg/day; 2-6 years: 12.5-25 mg q 6-8 hr, not to exceed 75 mg/day.
•IM, IV
Adults: 50 mg as required. Pediatric, over 2 years: 1.25 mg/kg (37.5 mg/m²) q.i.d., not to exceed 300 mg/day.
•IV
Adults: 50 mg in 10 mL sodium chloride injection given over 2 min; may be repeated q 4 hr as needed. Pediatric: 1.25 mg/kg (37.5 mg/m²) in 10 mL of 0.9% sodium chloride injection given slowly over 2 min; may be repeated q 6 hr, not to exceed 300 mg/day.