[.
]Action/Kinetics:
Possesses both glucocorticoid and mineralocorticoid activity. Short-acting. t1/2, plasma: 30 min; t1/2, biologic: 8-12 hr.
Uses:
Replacement therapy in chronic cortical insufficiency. Short-term (due to strong mineralocorticoid effect) for inflammatory or allergic disorders. Sterile suspension: Congenital adrenal hyperplasia in children.
Special Concerns:
Use during pregnancy only if benefits outweigh risks.
How Supplied:
Injection: 50 mg/mL; Tablet: 5 mg, 10 mg, 25 mg
Dosage
•Tablets, Injection
Initial or during crisis.
25-300 mg/day. Decrease gradually to lowest effective dose.
Anti-inflammatory.
25-150 mg/day, depending on severity of the disease.
Acute rheumatic fever.
200 mg b.i.d. day 1, thereafter, 200 mg/day.
Addison's disease.
Maintenance: 0.5-0.75 mg/kg/day.
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